Estimation of Dexketoprofen Effectiveness for Preemptive Analgesia in Patients with a Fracture of the Hip after Combined Trauma During Femoral Osteosynthesis

O.V. Voennov1, M.V. Karelsky1, A.O. Trofimov1,2, G.V. Kalentev2

1 Nizhny Novgorod State Medical Academy, Russian Federation, Nizhny Novgorod

2 Nizhny Novgorod Regional Clinical Hospital n.a. Semashko, Russian Federation, Nizhny Novgorod

For correspondence: Karelsky Mikhail Viktorovich, post graduate student of the Department of Anaesthesiology and Reanimatology Nizhny Novgorod State Medical Academy, Russian Federation, Nizhny Novgorod; e-mail: m.karelsky@mail.ru

For citation: Voennov OV, Karelsky MV, Trofimov AO, Kalentev GV. Estimation of Dexketoprofen Effectiveness for Preemptive Analgesia in Patients with a Fracture of the Hip after Combined Trauma During Femoral Osteosynthesis. Intensive Care Herald. 2017;4:29–35.


We have studied the effectiveness of dexketoprofen for preemptive analgesia in patients with a fracture of the hip after combined trauma during femoral osteosynthesis. We examined 120 patients of both sex. The patients were divided into 2 groups of 60 people depending on the use of preemptive analgesia. After that the group of 60 persons were divided into groups of 20 patients, depending on the type of anesthesia. Group 1A — inhalation anesthesia (IA). Group 1B — regional anesthesia (RA). Group 1С — total intravenous anesthesia (TIA). Group 2A — inhalation anesthesia (IA) and preemptive analgesia with dexketoprofen. Group 2B — regional anesthesia (RA) and preemptive analgesia with dexketoprofen. Group 2С — total intravenous anesthesia (TIA) and preemptive analgesia with dexketoprofen. All patients were provided with blocked intramedullary femoral osteosynthesis in 3–5 days after the trauma. Postoperative analgesia was provided with tramadol and trimeperidine. The study consisted of the following steps: 1st — before the surgery, 2nd — at the beginning of the operation, 3rd — after the transfer to the hospital ward, 4th — 24 hours after the surgery. We studied pain expression using the visual analog scale, hemodynamics, blood cortisol levels. After using dexketoprofen all patients had a more favorable pain severity dynamics, less blood cortisol levels, less blood pressure and heart rate in the early postoperative period.

Keywords: postoperative pain syndrome, combined trauma, anesthesia, postoperative analgesia, dexketoprofen, preemptive analgesia

Received: 02.08.2017


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