Experience of Treatment of Seasonal Influenza, Complicated by Viral and Bacterial Pneumonia: a Multicenter Retrospective Study

D.L. Shukevich1, G.P. Plotnikov1, L.E. Shukevich3, S.V. Voevodin4, E.A. Kameneva2, R.A. Kornelyuk1, S.V. Vostrikov3, D.C. Peredelkin3, P.G. Sitnikov4, E.F. Malyugin5, E.I. Tutolmin5, V.E. Shipakov5, E.V. Grigorev1

1 FGBNU «Institute for Complex Problems of cardiovascular disease», Kemerovo

2 MBUZ «City Clinical Hospital № 3», Kemerovo

3 GAUZ «Kemerovo Regional Clinical Hospital», Kemerovo

4 MLPU «City Clinical Hospital № 1», Novokuznetsk

5 GAUS «Tomsk Regional Clinical Hospital», Tomsk

For citation: Shukevich DL, Plotnikov GP, Shukevich LE, Voevodin SV, Kameneva EA, Kornelyuk RA, Vostrikov SV, Peredelkin DC, Sitnikov PG, Malyugin EF, Tutolmin EI, Shipakov VE, Grigorev EV. Experience of Treatment of Seasonal Influenza, Complicated by Viral and Bacterial Pneumonia: a Multicenter  Retrospective Study. Intensive Care Herald. 2016;2:46–50.


Тhe aim of the study. To conduct a comparative analysis of the experience of intensive care of severe viral-bacterial pneumonia, complicated by ARDS. Materials and methods. We conducted a retrospective analysis of clinical, historical, laboratory and instrumental data which were done by comparing the array of indicators for the periods (1) 2009 and (2) 2015–2016. We used the standard methods of investigations, including clinical, instrumental and laboratory methods. Results. The period 2015–2016 was characterized by an early hospitalization of patients in the ICU, a quick decision to intubate the patients and the rejection of non-invasive respiratory support, the expansion of indications for extrapulmonary oxygenation procedures and for renal replacement therapy.

Conclusions

  1. Following the principles of intensive treatment of severe viral and bacterial pneumonia flu season A(H1N1) have improved outcomes in the studied group of patients.
  2. Initial experience of the extracorporeal membrane oxygenation (ECMO) demonstrated the perspective for achieving optimal oxygenation without the ventilator-associated lung injury. The criteria for the initiation of ECMO can be moved into the area of critical values decrease the oxygen fraction, plateau pressure and positive end-expiratory pressure.
  3. Methods of renal replacement therapy with the use of membranes with the function of cytokine adsorption can neutralize the systemic inflammatory response.

Keywords: seasonal flue, acute respiratory distress syndrome, intensive care

Received: 09.05.2016


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