Molecular Mechanisms of Oxidative Stress

O.A. Grebenchikov1, 2, T.S. Zabelina1, Zh.S. Philippovskaya1, O.N. Gerasimenko1, E.Y. Plotnikov3, V.V. Likhvantsev1, 2

1M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow

2V.A. Negovsky Research Institute of General Reanimatology, Russian Academy of Sciences, Moscow

3Belozersky Institute of Physico-Chemical Biology, Lomonosov, Moscow

For correspondence: Oleg A. Grebenchikov — Ph.D., Senior Research Fellow of Anesthesiology and Intensive Care Department, Moscow, Regional Research and Clinical Institute, Moscow, Russia; e-mail:oleg.grebenchikov@yandex.ru

For citation: Grebenchikov OA, Zabelina TS, Philippovskaya ZhS, Gerasimenko ON, Plotnikov EY, Likhvantsev VV. Molecular Mechanisms of Oxidative Stress. Intensive Care Herald. 2016;3:13–21. 


The role of oxidative stress in the pathogenesis of various diseases, the treatment of which is within the competence of doctors-intensivists, seems to us undervalued. Perhaps unnoticed in the clinical environment appeared some progress has occurred in recent years in understanding the molecular mechanisms of oxidative stress. In contrast to the long-known toxic effect of ROS, to date, they are recognized as signaling molecules, leading to a protective effect in the cell, which has found confirmation in the study of the phenomenon of ischemic preconditioning and anesthetic. It proved the key role of mitochondrial ROS in the development and regulation of the apoptotic program in the cell, which is implemented through the induction of a giant mitochondrial pore. The discovery of the key role of the enzyme GSK -3b in inhibiting its induction led to the understanding that the retention of the kinase phosphorylated state is the primary task to prevent the death of the target organ cells. It seems that the understanding of the molecular mechanisms of cell death in ischemia / reperfusion lead to a focused search for pharmacological agents cytoprotection.

Keywords: oxidative stress, reactive oxygen species, GSK-3b, mitochondrial pore, mitochondria-targeted antioxidants

Received: 28.06.2016


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