New in the Treatment of Acute Respiratory Distress Syndrome

A.V. Vlasenko1, 2, D.P. Pavlov2, V.V. Kochergina2, D.A. Shestakov2, A.K. Doloksaribu2

1 FGBOU VPO «Department of Anesthesiology and Intensive Care in FUV People’s Friendship University», Moscow

2 City Clinical Hospital n.a. S.P. Botkin, Moscow

For citation: Vlasenko AV, Pavlov DP, Kochergina VV, Shestakov DA, Doloksaribu AK. New in the Treatment of Acute Respiratory Distress Syndrome. Intensive Care Herald. 2016;2:37–45.


Тhe aim of the study. The study of clinical efficiency and of the not differentiated and differentiated use of respiratory, non-respiratory and pharmacological treatments in patients with acute respiratory distress syndrome of different genesis. Materials and methods. In the prospective study 63 examined patients (38 men, 25 women, aged 22 to 68 years) with acute respiratory distress syndrome were divided into 2 groups. Group A (n = 30, 18 men, 12 women) and group B (n = 33, 20 men, 13 women). All patients had acute respiratory distress syndrome as a result of direct and indirect damage factors: aspiration of gastric contents, blunt chest trauma with lung injury, acute bilateral pneumonia, abdominal sepsis, severe concomitant injury without lung injury, acute massive blood loss. In group A undifferentiated use respiratory, non-respiratory and pharmacological treatments for ARDS. In group B these methods applied differentiated depending of the causes of ARDS. We studied the clinical efficiency not differentiated and the differentiated application of escalation or de-escalation PEEP optimized methods, lung recruitment, prone-position, Surfactant BL, Perftoran and their combined use. Results. Depending of the ARDS reasons differentiated use of respiratory, non-respiratory and pharmacological methods can improve results and reduce mortality in patients with ARDS. Conclusions. It is advisable to use a differentiated respiratory, non-respiratory and pharmacological treatment in patients with ARDS depending of the reasons of its development.

Keywords: acute respiratory distress syndrome, direct damaging factors, not direct damaging factors, mechanical ventilation, positive end-expiratory pressure, lung recruitment, prone-position, Surfactant BL, Perftoran

Received: 14.04.2016 


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