Procedural Xenon Sedation for Diagnostic Esophagogastroduodenoscopy

V.I. Potievskaya1, F.M. Shvetskiy2

1 «National Radiology Research Center» Russian Federation Ministry of Healthcare, Мoscow

2 2 Wars Veterans Hospital, Moscow

For correspondence: Vera I. Potievskaya — Ph.D., M.D., chief researcher “National Radiology Research Center”, Russian Federation Ministry of Healthcare; e-mail: vera.pot@mail.ru

For citation: Potievskaya VI, Shvetskiy FM. Procedural Xenon Sedation for Diagnostic Esophagogastroduodenoscopy. Intensive Care Herald. 2017;4:42–46.


We examined 18 healthy volunteers aged 25 to 39 years underwent esophagogastroduodenoscopy under sedation with xenon-oxygen mixture with xenon/oxygen ratio 70/30 %. A three-hole mask with inputs for endoscope, catheter, and gas mixture supply was used for inhalations. The duration of the inhalations was no more than 3 minutes. Patients’ satisfaction with anesthesia was evaluated with a questionnaire. We performed main hemodynamics parameters, heart rhythm variability and blood acid-base state monitoring during the procedure. All patients evaluated the anesthesia as satisfactory, none of the examined felt a foreign body during the esophagogastroduodenoscopy, there were no painful sensations and negative effects except excessive salivation. Mask anesthesia with xenon-oxygen mixture with concentration of 70/30 % for 3 minutes during diagnostic esophagogastroduodenoscopy did not cause significant changes in blood pressure and heart rate, as well as basic parameters of acid-base state. Saturation and oxygen partial pressure of blood increased due to inhalation of hyperoxic mixture. Assessment of heart rhythm variability demonstrated significant increase in general spectrum capacity reflecting rise of cardiovascular system reserves, and decrease in low and high spectrum frequency ratio due to reduction of sympathetic activity. The obtained results allow to draw a conclusion about sufficient efficiency and safety of anesthesia with xenon during diagnostic esophagogastroduodenoscopy in healthy volunteers.

Keywords: xenon, procedural sedation, esophagogastroduodenoscopy, satisfaction with anesthesia, heart rhythm variability

Received: 23.10.2017


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