Propofol Infusion Syndrome

A.A. Birkun, A.A. Babanin, M.A. Glotov, A.L. Govdalyuk, P.V. Mel’nychenko, N.Yu. Pylaeva, S.A. Samarin, M.I. Fedosov

Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University, Simferopol

For correspondence: Alexei A. Birkun — Cand. Sci. Med., assistant professor of the chair of anesthesiology-resuscitaion and emergency medicine in Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University; e-mail: birkunalexei@gmail.com

For citation: Birkun AA, Babanin AA, Glotov MA, Govdalyuk AL, Mel’nychenko PV, Pylaeva NYu, Samarin SA, Fedosov MI. Propofol Infusion Syndrome. Intensive Care Herald. 2016;3:38–42. 


Propofol infusion syndrome (PRIS) is rare but extremely dangerous complication of propofol administration that is characterized by increased mortality level. Pathogenesis of PRIS is represented by the conjunction of intensified lipolysis, disturbances of fatty acid oxidation and impaired mitochondrial respiratory chain function. PRIS typically develops in patients with critical conditions receiving continuous high-dose propofol infusion and presents as lactate acidosis, rhabdomyolysis and acute circulatory failure. For PRIS there is no specific treatment and the prognosis is largely determined by an ability of the clinician to recognize the syndrome early and stop propofol administration. This review provides a modern insight into pathogenesis, clinical presentations, preventive measures and intensive care of the syndrome and is generally intended to raise an alertness and improve understanding of the problem among practicing physicians.

Keywords: propofol infusion syndrome, PRIS, propofol, hyperlipidemia, rhabdomyolysis, acidosis, Brugada syndrome, ECMO

Received: 26.03.2016


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