Xenon anesthesia during the oral cavity sanitation in child with consequences of perinatal brain damage (case report)

V.V. Lazarev1, D.M. Haliullin2, R.R. Gabdrafikov2, E.S. Gracheva2, E.E. Kuznetsova3, D.V. Koshcheev2

1 «Pirogov Russian National Research Medical University», Moscow

2 LLC “Dental Forte Elit”, Naberezhnye Chelny

3 PAHI “Municipal Hospital No. 5’, Naberezhnye Chelny

For correspondence: Dinar M. Haliullin, doctor intensivist of LLC Dental Forte Elit, Naberezhnye Chelny; e-mail: dr170489@yandex.ru

For citation: Lazarev VV, Haliullin DM, Gabdrafikov RR, Gracheva ES, Kuznetsova EE, Koshcheev DV. Xenon anesthesia during the oral cavity sanitation in child with consequences of perinatal brain damage (case report). Alexander Saltanov Intensive Care Herald. 2019;2:105–110.

DOI: 10.21320/1818-474X-2019-2-105-110

Halogenated inhalation anesthetics have some adverse effects, including the ability to have a negative effect on the developing brain in children, one of the manifestations of which are cognitive dysfunctions, especially in the younger age group. The article presents a clinical case of xenon in combined inhalation anesthesia in a child with the consequences of perinatal brain damage. During anesthesia, a spontaneous ventilation mode was applied with pressure support ventilation (PSV). There was noted high efficacy and safety xenon anesthesia in a dental treatment, the absence of the effect of anesthesia on cognitive function in a child with a compromised nervous system. It is advisable to further study the use of xenon in the pediatric dentistry anesthesia.

Keywords: xenon, inhalation anesthesia, volatile anesthetics, children, dentistry

Received: 27.01.2019


  1. Китиашвили И.З., Буров Н.Е., Фрейлин И.С., Хрыкова Е.В. Динамика клеточного иммунитета и цитокинов под влиянием анестезии ксеноном и закисью азота. Анестезиология и реаниматология. 2006; 2: 4–9. [Kitiashvili I.Z., Burov N.E., Freylin I.S., Hrykova E.V. Dynamics of cellular immunity and cytokines under the influence of anesthesia xenon and nitrous oxide. Anesthesiology and resuscitation. 2006; 2: 4–9. (In Russ)]
  2. Довгуша В.В., Фок М.В., Зарницкая Г.А. Возможный и молекулярный механизм наркотического действия инертных газов. Биофизика. 2005; 50(5): 903–908. [Dovgusha V.V., Fok M.V., Zarnitskaya G.A. Possible and molecular mechanism of narcotic effect of inert gases. Biophysics. 2005; 50(5): 903–908. (In Russ)]
  3. Китиашвили И.З., Буров Н.Е. Сравнительная оценка гемодинамических, гормональных и метаболических показателей в условиях анестезии ксеноном и закисью азота. Вестник интенсивной терапии. 2006; 1: 57–60. [Kitiashvili I.Z., Burov N.E. Comparative assessment of hemodynamic, hormonal and metabolic indicators in the conditions of anesthesia xenon and nitrous oxide. Intensive care herald. 2006; 1: 57–60. (In Russ)]
  4. Китиашвили И.З., Хрыкова Е.В., Мухамеджанова С.А., Дьяконова Н.Г. Коррекция хирургического стресса при различных вариантах общей анестезии. Казанский медицинский журнал. 2006; 1: 23–28. [Kitiashvili I.Z., Hrykova E.V., Mukhamedzhanova S.A., Dyakonova N.G. Correction of a surgical stress at various options of the general anesthesia. The Kazan medical magazine. 2006; 1: 23–28. (In Russ)]
  5. Буров Н.Е., Джабаров Д.А., Колесова О., Шулунов М.В. Оксидантная и антиоксидантная система при анестезии ксеноном и закисью азота. Тезисы X Всероссийского пленума правления Федерации анестезиологов-реаниматологов. Нижний Новгород, 1995: 47–48. [Burov N.E., Dzhabarov D.A., Kolesova O., Shulunov M.V. An oxidatic and antioxidant system at anesthesia xenon and nitrous oxide. Theses of the X All-Russian plenum of board of federation of intensivists. Nizhny Novgorod, 1995: 47–48. (In Russ)]
  6. Суслов Н.И., Потапов В.Н., Шписман М.Н. и др. Применение ксенона в медицине. Томск: Изд-во Томского университета, 2009. [Suslov N.I., Potapov V.N., Shpisman M.N., et al. Use of xenon in medicine. Tomsk: Publishing house of the Tomsk university, 2009. (In Russ)]
  7. Шулунов М.В., Буров Н.Е. Влияние комбинированной анестезии закисью азота и ксеноном на гормональные показатели. Тезисы X Всероссийского пленума правления Федерации анестезиологов-реаниматологов. Нижний Новгород, 1995: 96–85. [Shulunov M.V., N.E. Burov. Influence of the combined anesthesia nitrous oxide and xenon on hormonal indicators. Theses of the X All-Russian plenum of board of federation of intensivists. Nizhny Novgorod, 1995: 96–85. (In Russ)]
  8. Шулунов М.В. Оценка адекватности ксеноновой анестезии по данным гормональных, гемодинамических и биохимических показателей: автореф. дис. … канд. мед. наук: 14.00.37. М., 1995. [Shulunov M.V. Assessment of the adequacy of xenon anesthesia according to hormonal, hemodynamic and biochemical parameters: autoref. yew. edging. medical sciences: 14.00.37. M., 1995. (In Russ)]
  9. Шурыгин В.В., Кутушев О.Т. Применение ингаляции ксенон-кислородной смеси в комплексной терапии тревожно-депрессивных расстройств. Ксенон и инертные газы в медицине: тез. докл. III Конф. анестезиологов-реаниматологов медицинских учреждений МО РФ (г. Москва, 24 апреля 2008 г.). М., 2008: 171–177. [Shurygin V.V., Kutushev O.T. Inhalation application xenon-oxygen mix in complex therapy is disturbing depressive frustration. Xenon and inert gases in medicine. The III Konf. intensivists of medical institutions of the Ministry of Defence of the Russian Federation (Moscow, on April 24, 2008). Moscow, 2008: 171–177. (In Russ)]
  10. Liang G., Ward C., Peng J., et al. Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. Anesthesiology. 2010; 112(6): 1325–1334. DOI: 10.1097 / ALN.0b013e3181d94da5
  11. Melzack R., Wall P.D. Pain mechanisms: a new theory. Science. 1965; 150(3699): 971–979. DOI: 10.1126/science.150.3699.971
  12. Yu Q., Wang H., Chen J., et al. Neuroprotections and mechanisms of inhalational anesthetics against brain ischemia. Front. Biosci (Elite E2). 2010; 1(4): 1275–1298.
  13. Ma D., Hossain M., Chow A., et al. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann. Neurol. 2005; 58(2): 182–193. DOI: 10.1002/ana.20547
  14. Luo Y., Ma D., Leong E., et al. Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Anesthesiology. 2008; 109(5): 782–789. DOI: 10.1097/aln.0b013e3181895f88
  15. Weber N.C., Stursberg J., Wirthle N.M., et al. Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo. Br. J. Anaesth. 2006; 97(3): 298–306. DOI: 10.1093/bja/ael153
  16. Shu Y., Patel S.M., Pac-Soo C., et al. Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Anesthesiology. 2010; 113(2): 360–368. DOI: 10.1097/ALN.0b013e3181d960d7
  17. Cremer J., Stoppe C., Fahlenkamp A.V., et al. Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial. Med. Gas. Res. 2011; 1(1): 9. DOI: 10.1186/2045-9912-1-9
  18. Fahlenkamp A.V., et al. Bispeknral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patient. Eur. J. Anaesth. 2010; 27: 10: 906–911.
  19. Gill H. Xenon-augmented pediatric anesthesia: A small step closer? Paediatr Anaesth. 2017; 27(12): 1174–1175. DOI: 10.1111/pan.13265
  20. Hucker J., et al. Differences between bispektral index and spectral entropy during xenon anaesthesia: a comparison with propofol anaesthesia. Anaesthesia. 2010; 65(6): 595–600. DOI: 10.1111/j.1365-2044.2010.06344.x
  21. Jin Z., Piazza O., Ma D., Scarpati G., De Robertis E. Xenon anesthesia and beyond: pros and cons. Minerva Anestesiol. 2019; 85(1): 83–89. DOI: 10.23736/S0375–9393.18.12909–9
  22. Kulikov A., Bilotta F., Borsellino B., et al. Xenon anesthesia for awake craniotomy: safety and efficacy. Minerva Anestesiol. 2019; 85(2): 148–155. DOI: 10.23736/S0375–9393.18.12406-0
  23. Law L.S., Lo E.A., Gan T.J. Xenon Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Anesth. Analg. 2016; 122(3): 678–697. DOI: 10.1213/ANE.0000000000000914
  24. Meloni E.G., Gillis T.E., Manoukian J., Kaufman M.J. Xenon impairs reconsolidation of fear memories in a rat model of post-traumatic stress disorder (PTSD). PLoS One. 2014; 9(8): e106189. DOI: 10.1371/journal.pone.0106189. eCollection 2014
  25. Stattman R., et al. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. DMC Anesthesiol. 2010; 10: 1. DOI: 10.1186/1471-2253-10-1
  26. Stoppe C., et al. AEPEX monitor for the measurement of hypnotic depth in patients undergoin balanced xenon anaesthesia. Dr. J. Anaesth. 2012; 108: 1: 80–88. DOI: 10.1093/bja/aer393.
  27. Vizcaychipi M.P., et al. Xenon anaesthesia may prevent early memory decline affect isoflurane anaesthesia and surgery in mice. HloS One 2011; 6: 11. DOI: 10.1371/journal.pone.0026394
  28. Xia Y., Fang H., Xu J., et al. Clinical efficacy of xenon versus propofol: A systematic review and meta-analysis. Medicine (Baltimore). 2018; 97(20): e10758. DOI: 10.1097/MD.0000000000010758.

Syndrome of Postnarcosis Excitation and its Prophylaxis in Anesthesia with Sevoflurane in Pediatric Oncology

S.V. Tumanyan, E.Yu. Semiletkina, D.A. Rozenko

Rostov Research Oncology Institute, Russian Federation Ministry of Healthcare of the Russian Federation, Rostov-on-Don

For correspondence: Tumanyan Sergey Vartanovich — MD, professor, head of the Department of Anesthesiology and Reanimatology of the Rostov Research Oncology Institute, Federal Ministry of Health, Rostov-on-Don; e-mail: stv53@mail.ru

For citation: Tumanyan SV, Semiletkina EYu, Rozenko DA. Syndrome of Postnarcosis Excitation and Its Prophylaxis in Anesthesia with Sevoflurane in Pediatric Oncology. Intensive Care Herald. 2017;2:31–36.

Sevoflurane is the «gold standard» in pediatric anesthesia, because Does not irritate the upper respiratory tract, has a cardioprotec- tive effect, is easily controlled. Along with this, sevoflurane also has side effects, of which the most interesting is the syndrome of post- narcotic excitement, expressed by expressed anxiety, motor excitement, negativism. For its prevention, dexmedetomidine can be used. The goal is to select the optimal method of prevention of post-nasal exacerbation syndrome (SPNV) in young children with oncological pathology with sevoflurane inhalation anesthesia. Materials and methods. 90 children with oncological pathology aged from 1 year to 4 years, body weight from 9 to 18 kg, physical status according to ASA II–III were examined. Depending on the method of prevention of SPNV, children were divided into three groups: 1st group of children who had undergone sevoflurane inhalation anesthesia; 2nd group of children who, after anesthesia with sevoflurane, received propofol, 3rd group — children who, prior to anesthesia with sevoflurane, intranasally injected dexmedetomidine. Conclusions. Administration of propofol at the end of inhalation with sevoflurane prevents the development of SPNV in children in 82.8% of cases, prolongs the phase of medicamentous sedation, reduces hypersympathicoto- nia. Short-term depression of respiration in response to the administration of propofol requires 100 % oxygen inhalation. Intranasal administration of dexmedetomidine 30 minutes prior to the onset of anesthesia prevents the development of SPNV in children after inhalation anesthesia with sevoflurane in 90% of cases.

Keywords: postnarcosis excitation syndrome, children, dexmedetomidine, sevoflurane, oncology

Received: 10.03.2017


  1. Сидоров В.А., Цыпин Л.Е., Гребенников В.А. Ингаляционная анестезия в педиатрии. М.: Медицинское информационное агентство, 2010: 65–68. [Sidorov A., Tsypin L.E., Grebennikov V.A. Ingalatsionnaya anesteziya v pediatrii. Moscow: MIA, 2010: 65–68. (In Russ)]
  2. Лазарев В.В., Цыпин Л.Е. Синдром постнаркозного возбуждения при ингаляционной анестезии севофлураном у детей. Анестезиология и реаниматология. 2010; 1: 62–66. [Lazarev V.V., Tsypin L.E. Sindrom postnarkoznogo vozbuzhdeniya pri ingalyztsionnoi anestezii sevofluranom u detei. Anest. i reanimat. 2010; 1: 62–66. (In Russ)]
  3. Сабинина Т.С., Губайдуллин Р.Р., Пасечник И.Н. и др. Методы профилактики постнаркозного возбуждения после анестезии севофлураном. Современное состояние проблемы. В сб.: Х науч.-практ. конф. «Безопасность больного в анестезиологии и реаниматологии». М., 2012. [Sabinina S., Gubaydullin R.R., Pasechnik I.N. et al. Metody profilaktiki postnarkosnogo vozbuzhdeniya posle anestezii sevofluranom. Sovremennoe sostoyanie problemy. In: Х nauch-prakt. conf. «Bezopasnost’ bol’nogo v anesteziologii i reanimatologii». Mos- cow, 2012. (In Russ)]
  4. Cravero P., Beach M., Dodgt C.P., Whalen K. Emergence characteristics of sevoflurane compared to halothane in pediatric patients undergoing bilateral pressure equalization tube insertion. J. Clin. Anaesth. 2000; 12(5): 397–401.
  5. Цыпин Л.Е., Лазарев В.В., Корсунский А.А. и др. Ингаляционный наркоз севораном (севофлураном) у детей (Медицинская технология): методич. пособие. М.: Изд-во РГМУ, [Tsypin L.E., Lazarev V.V., Korsunskiy A.A. et al. Ingalyatsionvyi narkoz sevoranom (sevofluranom) u detei (Meditsinskaya tehnologiya): metodich. posobie. Moscow: RGMU, 2008. (In Russ)]
  6. Игнатенко Д.Ю., Уткин С.И. Профилактика синдрома возбуждения при анестезии севофлураном в детской офтальмохирургии. В сб.: Федоровские чтения — VIII Всероссийская науч.-практ. конф. с международным участием. Сб. тезисов по материалам конф.: под ред. Х.П. Тахчиди. М., 2009. [Ignatenko D.Yu., Utkin S.I. Profilaktika sindroma vozbu- zhdeniya pri anestezii sevofluranom v detskoi oftal’mohirurgii. In: Fedorovskie chteniya — 2009. VIII Vserossiiskaya nauch.-pract. conf. s mezhdunarodnym uchastiem. Sb. tezisov po materialam conf.: ed.: Kh.P. Takhchidi. Moscow, 2009. (In Russ)]
  7. Bakhamees H.S., Mercan A., El-Halafawy M. Combination effect of low dose fentanyl and propofol on emergence agitation in children following sevoflurane anesthesia. Saudi Med. J. 2009; 30(4): 500–503. doi: 10.1097/MEG.0000000000000751.
  8. Abu-Shahwan I., Chowdary K. Ketamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anesthesia. Paediatr. Anaesth. 2007; 17(9): 846–850. doi: 1111/j.1460- 9592.2007.02298.x.
  9. Shibata S., Shigeomi S., Sato W., Enzan K. Nitrous oxide administration during washout of sevoflurane improves postanesthetic agitation in J. Anesth. 2005; 19(2): 160–163. doi: 10.4097/kjae.2014.66.1.34.
  10. Kulka J., Bressem M., Tryba M. Clonidine Prevents Sevoflurane-Induced Agitation in children. Anesth. Analg. 2001; 93(2): 335–338. doi: 10.1038/srep36553.
  11. Ibacache M.E., Muzon H.R., Brandes et.al. Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children. Anest. Analg. 2004; 98: 60–3.
  12. Цейтлин А.М. Применение пропофола в нейроанестезиологии. Российский журнал анестезиологии и интенсивной терапии. 1999; 1: 21–22. [Tseytlin A.M. Primenenie propofola v Rossiiskii zhurnal anesteziologii i intensivnoi terapii. 1999; 1: 21–22. (In Russ)]
  13. Шпанер Р.Я., Баялиева А.Ж. Влияние ингаляционного анестетика (севофлурана) и пропофола на внутричерепное давление при нейрохирургических вмешательствах. Российская нейрохирургия. 2009; 1: [Shpaner R.Ya., Bayalieva A. Zh. Vliyanie ingalatsionogo anestetika (sevoflurana) i propofola na vnutricherepnoe davlenie pri neirohirurgicheskih vmeshatel’stvah. Rossiiskaya neirohirurgiya. 2009; 1: 94. (In Russ)]
  14. Isik B., Arslan M., Tunga D. et al. Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery. Paediatr. Anaesth. 2006; 16: 748– 753. doi: 10.1111/j.1460-9592.2006.01845.x.
  15. Meng T., Xia Z.Y., Luo T. et al. Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study. Int. J. Paediatr. Otorhinolaryngol. 2012; 76: 1036–1041. doi: 10.1016/j.ijporl.2012.03.028.
  16. Дексдор (Дексмедетомидин): монография по препарату. М.: Orion Pharma, 2015: 13–14. [Deksdor (Deksmedetomidin): monografiya po Moscow: Orion Pharm, 2015: 13–14. (In Russ)]
  17. Afonso J., Reis F. Dexmedetomidine: current role in anesthesia and intensive Rev. Bras. Anestesol. 2012; 62(1): 118–133. doi: 10.1016/S0034-7094(12)70110-1.
  18. Neema K. Dexmedetomidine in pediatric cardiac anesthesia. Ann. Card. Anaesth. 2012; 15(3): 177–179. doi: 10.4103/0971- 9784.97972.
  19. Talke , Tayefeh F., Sessler D.I. et al. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology. 1997; 87(4): 835–841.
  20. Cheung C.W., Ng F., Lui J. et al. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br. J. Anaesth. 2011; 107: 430–437. doi: 10.1093/bja/aer164.
  21. Tobias D., Gupta P., Naguib A., Yates A.R. Dexmedetomidine: applications for the pediatric patient with congenital heart disease. Pediatr. Cardiol. 2011; 32(8): 1075–1087. doi: 10.1007/ s00246-011-0092-8.
  22. Sacurai , Obata T., Odaca A. et al. Buccal administration of dexmedetomidine as a preanesthetic in children. J. Anesth. 2010; 24: 49–53. doi: 10.1007/s00540-009-0863-z.
  23. Гуревич К.Г. Разработка систем интраназальной доставки лекарственных средств. Качественная клиническая практика. 2002; 1: 2–5. [Gurevich K.G. Razrabotka sistem intra- nazal’noi dostavki lekarstvennyh sredstv. Kachestvennaya klinicheskaya praktika. 2002; 1: 2–5. (In Russ)]

Clinical Parallels of the Tactics of Volemic Resuscitation and Nutritional Support with the Outcomes of Severe Thermal Burns in Children

K.S. Botvina, N.P. Pyshmintseva, N.P. Shen, Yu.Kh. Sayfitdinov, D.V. Suchkov

Department of anesthesiology and resuscitation of the Institute of continuous professional development Tyumen state medical university Ministry of Healthcare Russian Federation; Provincial clinical hospital № 1, Tyumen

For correspondence: Natalia Petrovna Shen — M.D., professor, chairman of department of anesthesiology and resuscitation of the institute of continuous professional development Tyumen GMU of the Ministry of Pub. Health of Russia, Tyumen; e-mail: nataliashen@rambler.ru

For citation: Botvina KS, Pyshmintseva NP, Shen NP, Sayfitdinov YuKh, Suchkov DV. Clinical Parallels of the Tactics of Volemic Resuscitation and Nutritional Support with the Outcomes of Severe Thermal Burns in Children. Intensive Care Herald. 2017;2:17–20.

In the article are studied the demographic, tactical and prognostic aspects of burn disease in children for the purpose of the devel- opment of the important clinical parallels, including of the mechanisms, which start the multiple organ system dysfunction, infectious complications and death. The results of a study showed that prevalence and the depth of defeat does not be determining for the possi- bility to master nourishment and it must not become the factor, which impedes the beginning of nutritional support within maximally early periods. The authors also established that the positive fluid balance administered for the first three days of ICU in children with the severe burns is not the predictor of complications or lethal outcome, which separates this population of patients from the number of majority of the patients, in whom the so-called Fluid overload is the independent factor of the risk of complications and lethal outcome.

Keywords: burn, children, severe thermal burns

Received: 08.03.2017


  1. Finkelstein A., Corso P.S., Miller T.R. Incidence and Economic Burden of Injuries in the United States. J. Epidemiol. Community Health. 2007; 61(10): 926. doi: 10.1136/jech.2007.059717.
  2. Thombs D., Singh V.A., Halonen J. et al. The effects of preexisting medical comorbidities on mortality and length of hospital stay in acute burn injury: evidence from a national sample of 31,338 adult patients. Ann. Surg. 2007; 245(4): 629–634. doi: 10.1097/01.sla.0000250422.36168.67.
  3. Klein B., Goverman J., Hayden D.L. et al. Benchmarking Outcomes in the Critically Injured Burn Patient. Ann. Surg. 2014; 259(5): 833–841. doi: 10.1097/SLA.0000000000000438.
  4. Kayilioglu S.I., Dinc , Sozen I. et al. Postoperative fluid management. World J. Crit. Care Med. 2015; 4(3): 192–201. doi: 10.5492/wjccm.v4.i3.192.
  5. Gunst , Derese I., Aertgeerts A. et al. Insufficient autophagy contributes to mitochondrial dysfunction, organ failure, and adverse outcome in an animal model of critical illness. Crit. Care Med. 2013; 41(1): 182–194. doi: 10.1097/CCM.0b013e3182676657.
  6. Глушкова Е.Г., Глушков В.С., Калинин Е.П. и др. Изменение проницаемости мембран эритроцитов для АТФ при их сдвиговой деформации в условиях активации свободно-радикального окисления. Медицинская наука и образование Урала, 2016; 3; 40–44. [Glushkova Ye.G., Glushkov V.S., Kalinin Ye.P. et al. Izmenenie pronitsaemosti membran eritrotsitov dlya ATF pri ih sdvigovoi deformatsii v usloviyah aktivatsii svobodno-radikal’nogo okisleniya. Meditsinskaya nauka i obrazovanie Urala. 2016; 3; 40–44. (In Russ)]
  7. Kraft R., Herndon D.N., Al-Mousawi A.M. et al. Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet. 2012; 379(9820): 1013–1021. doi: 1016/S0140-6736(11)61345-7.
  8. Lari A.R., Panjeshahin M.R., Talei R. et al. Epidemiology of childhood burn injuries in Fars province, Iran. J. Burn Care Rehabil. 2002; 23(1): 39–45.
  9. Шень Н.П., Поляков А.П., Сайфитдинов Ю.Х. Положение об оказании неотложной помощи пострадавшим с термической травмой в Тюменской области. Инструктивно-методич. указания. Тюмень: Академия, 2007. [Shen P., Polyakov A.P., Sayfitdinov Yu.Kh. Polozhenie ob okazanii neotlozhnoi pomoshchi postradavshim s termicheskoi travmoi v Tumenskoi oblasti. Instructivno-metodicheskie ukazaniya. Tyumen: Akademiya, 2007. (In Russ)]
  10. Shankar-Hari , Phillips G.S., Levy M. et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8): 775–787. doi: 10.1001/jama.2016.0289.
  11. Bernard R., Artigas A., Brigham KL, et al. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. J. Crit. Care. 1994; 9(1): 72–81.
  12. Лекманов А.У., Будкевич Л.И., Сошкина В.В. Оптимизация антибактериальной терапии у детей с обширной ожоговой травмой, основанная на уровне прокальцитонина. Вестник интенсивной терапии. 2009; 1; 33–38. [Lekmanov A.U., Budkevich L.I., Soshkina V.V. Optimizatsiya antibakterial’noi terapii u detei s obshirnoi ozhogovoi travmoi, osnovannaya na urovne prokal’tsitonina. Vestnik intensivnoy terapii. 2009; 1; 33–38. (In Russ)]