The influence of the composition of inhaled gas mixture in the inspiratory tidal volume and airway pressure during mechanical ventilation with controlled volume and pressure (experimental study)

I.N. Grachev, A.V. Shchegolev

Federal State Budget Military Educational Institution of Higher Education Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russian Federation, St. Petersburg

For correspondence: Ivan N. Grachev — adjunct of the department of anesthesiology and reanimatology Federal State Budgetary Educational Military Institution of Higher Education Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, St. Petersburg; e-mail: GrachewIN@mail.ru

For citation: Grachev IN, Shchegolev AV. The influence of the composition of inhaled gas mixture in the inspiratory tidal volume and airway pressure during mechanical ventilation with controlled volume and pressure (experimental study). Alexander Saltanov Intensive Care Herald. 2018;2:61–8.

DOI: 10.21320/1818-474X-2018-2-61-68


The aim of the study was to assess the effect of the composition of the inhaled gas mixture on the recorded indicators of inspiratory respiratory volume in ventilator with controlled volume, and inspiratory pressure in the Airways, in ventilator with controlled pressure. To carry out the ventilation with a mixture of helium and oxygen, the Hamilton G5 (Hamilton Medical, Switzerland) ventilator was used with a unit that provides the possibility of supplying this type of mixture. To simulate the lungs, we used TestChest Respiratory Flight Simulator (Organis GmbH, Switzerland) with settings reflecting the patientʼs respiratory system, both in normal and in pathological conditions. According to the results of the study, the composition of the inhaled gas mixture during lung ventilation with controlled volume does not affect the recorded inspiratory respiratory volume on the models of normal and pathological lungs. However, during artificial ventilation of lungs with a mixture of helium and oxygen with controlled pressure, statistically significant differences in the recorded inspiratory pressure in the Airways on the model of lungs were revealed in comparison with the mechanical ventilation oxygen-air mixture.

Keywords: mixture of helium and oxygen, oxygen-air mixture, mechanical ventilation of the lungs, the model of the lungs

Received: 03.05.2018


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