The Thromboelastography: Clinical Significance of Functional Fibrinogen Test

A.Yu. Bulanov1, 2, K.V. Yatsckov1, E.L. Bulanova1,3, N.V. Dobrova1

1 52th Moscow City hospital, Moscow

2 Russian University of Friendship, Moscow

3 First Moscow Medical University, Moscow

For correspondence: Bulanov Andrey Yulievich — Doctor of Medical Science, Head of consultative transfusiology team of 52th Moscow City hospital, Professor of Department of Anesthesiology and Reanimatology of Russian University of Friendship, Moscow; e-mail: buldoc68@mail.ru

For citation: Bulanov AYu, Yatsckov KV, Bulanova EL, Dobrova NV. The Thromboelastography: Clinical Significance of Functional Fibrinogen Test. Intensive Care Herald. 2017;1:5–11.


The hemostatic system is a frequent subject of interest of critical care. Critical hemostasis has been studied most commonly using thromboelastography. Presented study report the experience in the use of special TEG technology fictional fibrinogen test. As the main working area of FF-test should be marked posthemorrhagic coagulopathy, a situation demanding close attention to the function of the platelets when combined with hyperfibrinogenemia (increase in fibrinogen associated with nonspecific inflammation, gestational hyperofibrinogenemia). A significant difference (more than 2 g/l) between the level of fibrinogen of the plasma is estimated by the method of Claus and FF-test can serve as a marker of dysfibrinogenemia. The clinical importance of the methodology is a predictor of thrombotic and haemorrhagic problems, the diagnostic marker, a reference point for the purpose of transfusion therapy.

Keywords: thromboelastography, functional fibrinogen, bleeding, thrombosis, intensive care

Received: 21.01.2017 


References

  1. Harr J.N., Moore E.E., Chasabyan A. et al. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013; 39(1): 45–19. doi: 10.1097/SHK.0b013e3182787122.
  2. Parker R.J., Eley K.A., Von Kier S. et al. Functional fibrinogen to platelet ratio using thromboelastography as a predictive parameter for thrombotic complications following free tissue transfer surgery: a preliminary study. 2012; 32(7): 512–519. doi: 10.1002/micr.21978.
  3. Буланов А.Ю. Тромбоэластография в современной клинической практике. Атлас ТЭГ. М.: Ньюдиамед, 2015. [Bulanov A.Yu. Tromboelastografiya v sovremennoi klinicheskoi praktike. Atlas TEG. Moscow: N’udiamed, 2015. (In Russ)]
  4. Chen A., Teruya J. Global hemostasis testing thromboelastography: old technology, new applications. Clin. Lab. Med. 2009; 29: 391–407. doi: 10.1016/j.cll.2009.04.003.
  5. Solomon C., Ranucci M., Hochleitner G. et al. Assessing the methodology for calculating platelet contribution to clot strength in thromboelastometry and thromboelastography. Analg. 2015; 121: 868–878. doi: 10.1213/ANE.0000000000000859.
  6. Carroll R.C., Craft R.M., Chavez J.J. et al. Measurement of functional fibrinogen levels using the thrombelatograph. Clin. Anesth. 2008; 20(3): 186–190. doi: 10.1016/j.jclinane.2007.09.017.
  7. Pruller F., Raggan R.B., Mahla E. et al. Whole blood fibrinogen test results in thromboelastography and thromboelastometry — which one is true? Transfusion Med.. 2014: 24(suppl. 1): 45.
  8. De Pietry L., Raqusa F., Deleuterio A. et al. Reduce transfusion during OLT by POC coagulation management and TEG fictional fibrinogen. Transplant Direct. 2015; 2(1): 49. doi: 10.1097/TXD.0000000000000559.
  9. Fluger I., Maderova K., Simek M. et al. Comparison of functional fibrinogen assessment using thromboelastography with the standard von Clauss method. Biomed. Pap. Med. Fac. Univ. Olomouc. Czech. Repub. 2012; 156: 260–261. doi: 10.5507/bp.2011.035.