Toxic Epidermal Necrolysis, Problems of Diagnosis and Therapy

A.S. Pоvzun1, K.M. Krylov1, P.K. Krylov1, I.B. Furman1, I.E. Belousova2, K.E. Michunskii1, O.V. Orlova1

1 Saint-Petersburg I.I. Dzhanelidze research institute of emergency medicine, Saint-Petersburg

2 Federal State Budgetary Educational Military Institution of Higher Professional Education Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Saint-Petersburg

For correspondence: Orlova Olga Viktorovna — Candidate of Medical Science, senior researcher of the Department of burn injury Saint-Petersburg I.I. Dzhanelidze research institute of emergency medicine, Saint-Petersburg; e-mail: olgaviktes@yandex.ru

For citation: Pоvzun AS, Krylov KM, Krylov PK, Furman IB, Belousova IE, Michunskii KE, Orlova OV. Toxic Epidermal Necrolysis, Problems of Diagnosis and Therapy. Intensive Care Herald. 2017;2:69–75.


The article discusses modern ideas about the etiology, pathogenesis, diagnosis and treatment of toxic epidermal necrolysis (TEN) is a potentially life-threatening muco-cutaneous reactions. Given a description of two clinical cases.

Keywords: toxic epidermal necrolysis, Stevens—Johnson syndrome, Lyell’s syndrome, apoptosis of keratinocytes, granulysin, health and economic standard

Received: 22.12.2016


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