Use of Presepsin and Nitric Oxide Metabolites in Pediatric Oncology Patients with Infectious Complications

E.G. Golovnya, A.V. Sotnikov, V.N. Baykova, O.P. Petina

N.N. Blokhin Russian Cancer Research Center, Moscow

For correspondence: Sotnikov Anatoly Bjacheslavovich — Ph.D, Senior Research Officer, Department of anesthesiology and reanimatology of N.N. Blokhin Russian Cancer Research Center; e-mail: abcv@mail.ru

For citation: Golovnya EG, Sotnikov AV, Baykova VN, Petina OP. Use of presepsin and nitric oxide metabolites in pediatric oncology patients with infectious complications. Intensive Care Herald. 2016;3:43–46.


Early diagnostics of infectious complications is an actual problem of modern medicine. Application of different methods of laboratory biomarkers of sepsis allows to differentiate between different pathological conditions by its severity (from SIRS to septic shock and multi-organ failure), that seems to be crucial in prognosis. Differences in concentration of presepsin (PSP) and nitric oxide metabolites (sum of nitrates and nitrites) in two groups of pediatric patient with oncological diseases are presented in current research (р < 0.05). There was no statistically significant correlation between these biomarkers in both groups of patients. Our data showed evidence that growth of concentration of PSP and simultaneous drawdown of concentration of NOx could be a factor of poor prognosis in patients with infectious complications.

Keywords: biomarkers of sepsis, pediatric oncology, presepsin, nitric oxide

Received: 06.03.2016


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