Clinical case of treatment of patient with aHUS in obstetrical practice. Experience of anesthesiology and resuscitation department


A.V. Yakubov1, G.N. Salogub1, E.V. Komlichenko1, T.V. Kirsanova2

1 Almazov National Medical Research Centre, Saint-Petersburg

2 Federal State Institution “Research Center for Obstetrics, Gynecology and Perinatology” Ministry of Healthcare of Russian Federation, Moscow

For correspondence: Andrey V. Yakubov — head of Department of anesthesiology and critical care for adult patients of Specialized Perinatal Center of Almazov National Medical Research Centre, St. Petersburg; e-mail:

For citation: Yakubov AV, Salogub GN, Komlichenko EV, Kirsanova TV. Clinical case of treatment of patient with aHUS in obstetrical practice. Experience of anesthesiology and resuscitation department. Alexander Saltanov Intensive Care Herald. 2018;2:87–94.

DOI: 10.21320/1818-474X-2018-2-87-94

Atypical hemolytic-uremic syndrome (aHUS), a variant of thrombotic microangiopathy (TMA), is a life-threatening disease that leads to multiple organ damage with the high rate of maternal mortality or the disability of surviving. Our experience of the clinical course of the disease, launched after delivery, features of multiple organ failure, intensive care unit monitoring and treatment is presented in the article. We suggest, timely diagnosis and early specific anticomplementary therapy with complex and escalation treatment of multiple organ failure, which can be realized only in large multidisciplinary medical centers, can contribute to the improvement of outcomes.

Keywords: thrombotic microangiopathy, atypical hemolytic-uremic syndrome, eculizumab, obstetrics, multiple organ failure

Received: 15.05.2018

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