Intensive treatment of ovarian hyperstimulation syndrome. Clinical guidelines (treatment protocol)


L.V. Adamyan1, N.V. Artymuk2, T.E. Belokrinickaya3, A.V. Kulikov4, D.V. Marshalov5, A.P. Petrenko5, I.A. Salov5, O.S. Filippov6, E.M. Shifman7

1 FGBU «National medical research center for obstetrics, gynecology and perinatology named after V.I. Kulakov» Ministry of Health of Russia, Moscow

2 FGBOU VO “Kemerovo State Medical University” Ministry of Health of Russia, Kemerovo

3 FGBOU VO “Chita State Medical University” Ministry of Health of Russia, Chita

4 FGBOU VO “Uralʼsk State Medical University” Ministry of Health of Russia, Uralʼsk

5 FGBOU VO “Saratov State Medical University named after V.I. Razumovskij” Ministry of Health of Russia, Saratov

6 FGAOU VO “Moscow State Medical University named after I.M. Sechenov” Ministry of Health of Russia, Moscow

7 GBUZ MO “Moscow Regional Scientific Research Clinical Institute named after M.V. Vladimirsky”, Moscow

For correspondence: Marshalov Dmitrij — PhD, Associate Professor at the Department of Simulation Technologies and Emergency Medicine of the Saratov State Medical University named after V.I. Razumovskij, Saratov; e-mail:

For citation: Adamyan L.V., Artymuk N.V., Belokrinickaya T.E., Kulikov A.V., Marshalov D.V., Petrenko A.P., Salov I.A., Filippov O.S., Shifman E.M. Intensive treatment of ovarian hyperstimulation syndrome. Clinical guidelines (treatment protocol). Alexander Saltanov Intensive Care Herald. 2018;4:8–25.

DOI: 10.21320/1818-474X-2018-4-8-25

Ovarian hyperstimulation syndrome (OHSS) is a systemic disease that develops as a result of activation of the production of vasoactive mediators by the ovaries against the background of stimulation of superovulation. OHSS is characterized by an increase in the permeability of the capillary walls, which leads to the release of intravascular fluid into the extravascular space, its accumulation in the third space and hemoconcentration. Severe OHSS is characterized by the risk of thrombosis, impaired liver function, kidney function and the occurrence of adult respiratory distress syndrome (ARDS). In these clinical guidelines, the main provisions for the prognosis, diagnosis, prevention and intensive care of OHSS are presented, including the principles of treatment of intra-abdominal hypertension (IAH).

Keywords: ovarian hyperstimulation syndrome, intensive care, OHSS prevention

Received: 23.10.2018

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