Procedural Xenon Sedation for Diagnostic Esophagogastroduodenoscopy


V.I. Potievskaya1, F.M. Shvetskiy2

1 «National Radiology Research Center» Russian Federation Ministry of Healthcare, Мoscow

2 2 Wars Veterans Hospital, Moscow

For correspondence: Vera I. Potievskaya — Ph.D., M.D., chief researcher “National Radiology Research Center”, Russian Federation Ministry of Healthcare; e-mail:

For citation: Potievskaya VI, Shvetskiy FM. Procedural Xenon Sedation for Diagnostic Esophagogastroduodenoscopy. Intensive Care Herald. 2017;4:42–46.

We examined 18 healthy volunteers aged 25 to 39 years underwent esophagogastroduodenoscopy under sedation with xenon-oxygen mixture with xenon/oxygen ratio 70/30 %. A three-hole mask with inputs for endoscope, catheter, and gas mixture supply was used for inhalations. The duration of the inhalations was no more than 3 minutes. Patients’ satisfaction with anesthesia was evaluated with a questionnaire. We performed main hemodynamics parameters, heart rhythm variability and blood acid-base state monitoring during the procedure. All patients evaluated the anesthesia as satisfactory, none of the examined felt a foreign body during the esophagogastroduodenoscopy, there were no painful sensations and negative effects except excessive salivation. Mask anesthesia with xenon-oxygen mixture with concentration of 70/30 % for 3 minutes during diagnostic esophagogastroduodenoscopy did not cause significant changes in blood pressure and heart rate, as well as basic parameters of acid-base state. Saturation and oxygen partial pressure of blood increased due to inhalation of hyperoxic mixture. Assessment of heart rhythm variability demonstrated significant increase in general spectrum capacity reflecting rise of cardiovascular system reserves, and decrease in low and high spectrum frequency ratio due to reduction of sympathetic activity. The obtained results allow to draw a conclusion about sufficient efficiency and safety of anesthesia with xenon during diagnostic esophagogastroduodenoscopy in healthy volunteers.

Keywords: xenon, procedural sedation, esophagogastroduodenoscopy, satisfaction with anesthesia, heart rhythm variability

Received: 23.10.2017


  1. Russon K., Thomas A. Anaesthesia for day surgery. Perioper. Pract. 2007; 17(7): 302–307.
  2. Lee J.H. Anesthesia for ambulatory Korean J. Anesthesiol. 2017; 70(4): 398–406. doi: 10.4097/kjae.2017.70.4.398.
  3. Teunkens A., Vanhaecht K., Vermeulen K., Fieuws S., van de Velde M. et al. Measuring satisfaction and anesthesia related outcomes in a surgical day care centre: A three-year single-centre observational J Clin. Anesth. 2017; 43: 15–23. doi: 10.1016/j.jclinane.2017.09.007.
  4. Fregene T., Wintle S., Venkat Raman V. et al. Making the experience of elective surgery better. BMJ Open Quality, 2017; 6: e000079. doi:10.1136/bmjoq-2017-000079.
  5. Padmanabhan A., Frangopoulos C., Shaffer L.E.T. Patient satisfaction with propofol for outpatient colonoscopy: a prospective, randomized, double-blind Dis. Colon. Rectum. 2017; 60(10): 1102–1108. doi: 10.1097/DCR.0000000000000909.
  6. Shabashev S., Fouad Y., Huncke T.K., Roland J.T. Cochlear implantation under conscious sedation with local anesthesia; Safety, Efficacy, Costs, and Satisfaction. Cochlear Implants Int. 2017; 18(6): 297–303. doi: 1080/14670100.2017.1376423.
  7. Bruderer U., Fisler A., Steurer M.P., Steurer M., Dullenkopf A. Post-discharge nausea and vomiting after total intravenous anaesthesia and standardised PONV prophylaxis for ambulatory surgery. Acta Anaesthesiol. Scand. 2017; 61(7): 758–766. doi: 1111/aas.12921.
  8. Beaussier M., Albaladejo P., Sciard D., Jouffroy L., Benhamou D. et al. SFAR committee of ambulatory anaesthesia. Operation and organisation of ambulatory surgery in Results of a nationwide survey; The OPERA study. Anaesth. Crit. Care Pain Med. 2017; S2352–5568(17)30117–0. doi: 10.1016/ cpm.2017.07.003.
  9. Буров Н.Е., Потапов В.Н. Ксенон в медицине: очерки по истории и применению медицинского ксенона. М.: Пульс, 2012. [Burov N.E., Potapov V.N. Xenon in medicine: essays in history and use of medical xenon. M.: Pulʼs, 2012. (In Russ)]
  10. Наумов С.А., Хлусов И.А. Адаптационные эффекты ксенона. Интенсивная терапия. 2007; 1: 10–16. [Naumov S.A., Hlusov I.A. Adaptive effects of xenon. Intensivnaya terapiya. 2007; 1: 10–16. (In Russ)]
  11. Бухтияров И.В., Кальманов А.С., Кисляков Ю.Ю., Никифоров Д.А., Чистов С.Д., Шветский Ф.М., Бубеев Ю.А. Исследование возможности применения ксенона в тренировочном процессе для коррекции функционального состояния спортсменов. Лечебная физкультура и спортивная медицина. 2010; 6: 22–29. [Buhtiyarov I.V., Kalʼmanov A.S., Kislyakov Yu.Yu., Nikiforov D.A., Chistov S.D., Shvetskij F.M., Bubeev Yu.A. Study of possibility of xenon use in the training process for correction of functional status in Lecheb. fizkulʼt. i sport. med. 2010; 6: 22–29. (In Russ)]
  12. Буров Н.Е. Представления о механизме анестезиологических и лечебных свойств ксенона. Анестезиология и реаниматология. 2011; 2: 58–62. [Burov N.E. Conception of mechanisms of anesthesiological and therapeutic xenon properties. Anesteziologiya i reanimatologiya. 2011; 2: 58– (In Russ)]
  13. Козлов И.А. Ксенон при кардиохирургических операциях. Комплексный анализ. Вестник интенсивной терапии. 2007; 3: 45–53. [Kozlov I.A. Xenon in cardiac Complex analysis. Vestnik intensivnoj terapii. 2007; 3: 45–53. (In Russ)]
  14. Рощин И.Н., Шветский Ф.М., Ачкасов Е.Е., Довгуша В.В., Бутаков Г.Л., Чурилова О.В. Изобретение «Способ повышения работоспособности и нормализации функционального состояния организма человека посредством ксенонотерапии». Патент № 2580975/14.10.2014. [Roshchin I.N., Shvetskij F.M., Achkasov E.E., Dovgusha V.V., Butakov G.L., Churilova O.V. Izobretenie “Sposob povysheniya rabotos- posobnosti i normalizacii funkcionalʼnogo sostoyaniya organizma cheloveka posredstvom ksenonoterapii”. Patent RUS № 2580975/14.10.2014. (In Russ)]
  15. Рощин И.Н., Бутаков Г.Л., Кухаренко А.В., Швет- ский Ф.М. Полезная модель «Закрытый дыхательный контур для ингаляции ксенонокислородной смесью». Патент № 84708/22.01.2009. [Roshchin I.N., Butakov G.L., Kuharenko A.V., Shvetskij F.M. Poleznaya modelʼ “Zakrytyj dyhatelʼnyj kontur dlya ingalyacii ksenonokislorodnoj smesʼyu”. Patent RUS № 84708/2015. (In Russ)]
  16. Михайлов В.М. Вариабельность ритма сердца. Опыт практического применения метода. Иваново, [Mihajlov V.M. Variabelʼnostʼ ritma serdca. Opyt prakticheskogo primeneniya metoda. (Heart rhythm variability. Experience of practical use). Ivanovo, 2000. (In Russ)].