The Thromboelastography: Clinical Significance of Functional Fibrinogen Test

A.Yu. Bulanov1, 2, K.V. Yatsckov1, E.L. Bulanova1,3, N.V. Dobrova1

1 52th Moscow City hospital, Moscow

2 Russian University of Friendship, Moscow

3 First Moscow Medical University, Moscow

For correspondence: Bulanov Andrey Yulievich — Doctor of Medical Science, Head of consultative transfusiology team of 52th Moscow City hospital, Professor of Department of Anesthesiology and Reanimatology of Russian University of Friendship, Moscow; e-mail:

For citation: Bulanov AYu, Yatsckov KV, Bulanova EL, Dobrova NV. The Thromboelastography: Clinical Significance of Functional Fibrinogen Test. Intensive Care Herald. 2017;1:5–11.

The hemostatic system is a frequent subject of interest of critical care. Critical hemostasis has been studied most commonly using thromboelastography. Presented study report the experience in the use of special TEG technology fictional fibrinogen test. As the main working area of FF-test should be marked posthemorrhagic coagulopathy, a situation demanding close attention to the function of the platelets when combined with hyperfibrinogenemia (increase in fibrinogen associated with nonspecific inflammation, gestational hyperofibrinogenemia). A significant difference (more than 2 g/l) between the level of fibrinogen of the plasma is estimated by the method of Claus and FF-test can serve as a marker of dysfibrinogenemia. The clinical importance of the methodology is a predictor of thrombotic and haemorrhagic problems, the diagnostic marker, a reference point for the purpose of transfusion therapy.

Keywords: thromboelastography, functional fibrinogen, bleeding, thrombosis, intensive care

Received: 21.01.2017 


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Experience with the use of antithrombin III concentrate in a multidisciplinary clinic

I.S. Kiriienko1, A.Yu. Bulanov1, 2, I.B. Simarova2, S.V. Dzuba2

1 Peoples’ Friendship University of Russia, Moscow

2 City Clinical Hospital № 52, Moscow

For correspondence: Kiriienko Iryna Sergeevna — resident of the anesthesiology and intensive care department, medical institute, RUDN, Moscow

For citation: Kiriienko IS, Bulanov AYu, Simarova IB, Dzyuba SV. Experience with the use of Antithrombin III concentrate in a multidisciplinary clinic. Alexander Saltanov Intensive Care Herald. 2018;2:46–50.

DOI: 10.21320/1818-474X-2018-2-46-50

Thrombosis and thromboembolism are one of the frequent serious and complications in all groups of patients and can lead to death. The purpose of our study was to analyze the clinical situations that required the use of antithrombin concentrate in the practice of intensive care units within the framework of a multidisciplinary hospital. A retrospective analysis was performed of the treatment of 38 patients with acquired antithrombin deficiency in 2016, which was treated with antithrombin. The analysis of the clinical situations that required the use of antithrombin concentrate revealed that the most frequent need for the use of the drug occurs in patients with malignant blood diseases, liver and kidney diseases and in patients with sepsis. Also, the calculation methods for determining the required dosage do not provide an optimal level of AT activity, and the efficacy of anticoagulant therapy does not depend on the total dosage of the drug administered.

Keywords: antithrombin, anticoagulant therapy, thrombosis, thromboembolism

Received: 12.03.2018

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