The efficacy of VAP prophylaxis bundle


O.V. Ignatenko1,3, A.O. Bykov1,3, I.N. Tyurin2,3, E.B. Gelfand3, D.N. Protsenko1,3

1 Yudin city hospital, Moscow

2 Buyanov city hospital, Moscow

3 Department of anesthesiology and critical care medicine, Pirogov Russian National Research Medical University (RNRMU), Moscow

For correspondence: Denis Protsenko — MD, PhD, the Head of department of anesthesiology and critical care medicine, Pirogov Russian National Research Medical University, superintendent Yudin city hospital, Chief Anesthesiology and CCM Officer, Moscow; e-mail:

For citation: Ignatenko OV, Bykov AO, Tyurin IN, Gelfand EB, Protsenko DN. The efficacy of VAP prophylaxis bundle. Alexander Saltanov Intensive Care Herald. 2018;3:39–45.

DOI: 10.21320/1818-474X-2018-3-39-45

Objective: to evaluate efficacy of VAP prophylaxis bundle.

Methods: 79 ICU pts were included in RCT. The reason of invasive mechanical ventilation was the depression of consciousness due to stroke or head injury. The pts were randomized to VAP prophylaxis bundle group 1 or to standard care group 2. In first group we used bundle including filter and HME, special antimicrobial ventilator circuit, closed aspiration system and special oral hygiene system. The oral care performed 3 time per 24 hours with visual inspection, 0,05 % chlorhexidine solution washing, dental and gun cleaning, only closed system aspiration.

Results: VAP prophylaxis bundle decrease early onset VAP — 6.6 and 33 % in 1 and 2 groups respectively (p = 0.00167), increase VAP free-day — 7.5 ± 4.6 day in 1 group and 5.3 ± 6.5 day, (p = 0.00182) in group 2; decrease severity of VAP — CPIS on day 7 was 5.96 ± 3.2 and 7.2 ± 2.43 in 1 and 2 groups (p = 0.046), P/F on day 7 — 304.84 ± 22 and 255.9 ± 43 in 1 and 2 groups (p = 0.001).

The multivariate analysis show that oral care protocol was he most significant part of bundle (OR 0.21, 0.15–0.61 95 % CI; p = 0.00014). Microbiology data show decrease of CFU colonization Klebsiella pneumoniae from 106 to 104 (p < 0.001), Streptococcus pneumoniae from 107 to 103 (p < 0.001), MRSA from 105 to 103 (p < 0.001), Proteus mirabilis from 107 to 103 (p < 0.001).

Conclusions: VAP prophylaxis bundle decrease “early onset” VAP, severity of VAP, increase VAP free day.

Keywords: NP, VAP, ICU, VAP prophylaxis

Received : 07.08.2018

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