To the question about factors influencing neuromuscular blockade


G.G. Bestaev, V.D. Slepushkin

North-Ossetian State Medical Academy, Vladikavkaz

For correspondence: Georgy Bestaev — assistant of Department of anesthesiology and critical care medicine of North-Ossetian State Medical Academy; e-mail:

For citation: Bestaev GG, Slepushkin VD. To the question about factors influencing neuromuscular blockade. Alexander Saltanov Intensive Care Herald. 2018;2:36–9.

DOI: 10.21320/1818-474X-2018-2-36-39

It has long been known that the duration of the action of muscle relaxants is affected by a variety of factors, and to a greater extent this effect is observed when using non-depolarizing muscle relaxants of medium and long duration. Surprisingly, factors, influencing neuromuscular block, are not becoming the subject of scientific discussion and are not reflected in modern literature. It is absolutely obvious at the same time that the study of quantitative dynamics of neuromuscular block represents a significant scientific and practical interest. In the given literature review the most important factors will be considered and discussed.

Keywords: factors, muscle relaxants, neuromuscular block, inhalational anesthetics, smoking, electrolytes, temperature, circadian rhythm

Received: 07.02.2018

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