Опыт применения концентрата антитромбина в многопрофильной клинике

Ирина Сергеевна Кириенко; А. Ю. Буланов; И. Б. Симарова; С. В. Дзюба

doi:10.21320/1818-474X-2018-2-46-50

No. 2 (2018), INTENSIVE CARE IN HAEMOSTASIS DISORDERS

No. 2 (2018)

INTENSIVE CARE IN HAEMOSTASIS DISORDERS

Experience with the use of antithrombin III concentrate in a multidisciplinary clinic

Published 24.06.2018

Iryna Sergeevna Kiriienko⁺⁻
A.Yu. Bulanov⁺⁻
I.B. Simarova⁺⁻
S.V. Dzuba⁺⁻

Iryna Sergeevna Kiriienko

Peoples’ Friendship University of Russia, Moscow

https://orcid.org/0000-0003-3311-375X

A.Yu. Bulanov

Peoples’ Friendship University of Russia, Moscow; City Clinical Hospital № 52, Moscow

https://orcid.org/0000-0001-6999-8145

I.B. Simarova

City Clinical Hospital № 52, Moscow

https://orcid.org/0000-0002-9042-3917

S.V. Dzuba

City Clinical Hospital № 52, Moscow

https://orcid.org/0000-0002-0144-4207

PDF_2018-2_46-50 (Russian)

Keywords

antithrombin
anticoagulant therapy
thrombosis
thromboembolism

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Kiriienko I.S., Bulanov A.Y., Simarova I.B., Dzuba S.V. Experience with the use of antithrombin III concentrate in a multidisciplinary clinic. Annals of Critical Care. 2018;(2):46-50. doi:10.21320/1818-474X-2018-2-46-50

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Thrombosis and thromboembolism are one of the frequent serious and complications in all groups of patients and can lead to death. The purpose of our study was to analyze the clinical situations that required the use of antithrombin concentrate in the practice of intensive care units within the framework of a multidisciplinary hospital. A retrospective analysis was performed of the treatment of 38 patients with acquired antithrombin deficiency in 2016, which was treated with antithrombin. The analysis of the clinical situations that required the use of antithrombin concentrate revealed that the most frequent need for the use of the drug occurs in patients with malignant blood diseases, liver and kidney diseases and in patients with sepsis. Also, the calculation methods for determining the required dosage do not provide an optimal level of AT activity, and the efficacy of anticoagulant therapy does not depend on the total dosage of the drug administered.

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References

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