Clinical efficacy of metabolically active fluid therapy in patients with fat embolism syndrome

A.Yu. Yakovlev1, A.A. Pevnev1, M.S. Belous1, S.A. Tezyaeva3, D.V. Ryabikov2, S.I. Chistyakov1, T.A. Galanina1

1 Nizhniy Novgorod regional clinical hospital named after N.A. Semashko, Nizhniy Novgorod

2 Nizhny Novgorod clinical hospital 13, Nizhniy Novgorod

3 Nizhny Novgorod clinical hospital 5, Nizhniy Novgorod

For correspondence: Aleksey Y. Yakovlev — Sc. D., Associate Prof., ICU curator of “Nizhniy Novgorod regional clinical hospital named after N.A. Semashko”, Nizhniy Novgorod; е-mail: aritnnru@list.ru

For citation: Yakovlev AYu, Pevnev AA, Belous MS, et al. Clinical efficacy of metabolically active fluid therapy in patients with fat embolism syndrome. Alexander Saltanov Intensive Care Herald. 2018;2:51–6.

DOI: 10.21320/1818-474X-2018-2-51-56


The research tested changes of organ disorders in 22 patients with fat embolism syndrome in the early posttraumatic period. It was found that early multiple organ failure is related to traumatic shock. At Day 1 and thereafter, in patients with the severe combined injury, multiple organ failure was associated with manifesting fat embolism. We confirmed the efficacy of multiple substrate antihypoxant fluid to prevent multiple organ failure related to fat embolism manifesting in the early post-traumatic period.

Keywords: trauma, fat embolism, SOFA, methionine, succinate

Received: 29.12.2017


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