Modern Possibilities of Safe Use of Dexmedetomidine in Premedication for Endoscopic Cholecystectomy

I.Z. Kitiashvili1,2, V.Yu. Kireev1,2, S.V. Сhukarev1, D.I. Kitiashvili1, A.A. Salo1, I.I. Timirbulatov1

1 Astrakhan State Medical University Russian Ministry of Health, Astrakhan

2 Occupational Health Facility, Astrakhan 

For correspondence: I.Z. Kitiashvili — MD, professor, head of Department of Anesthesiology and Intensive Care of State Budget Educational Institution of Higher Professional Education “The Astrakhan State Medical University”, Astrakhan; e-mail: kitiashvili@mail.ru

For citation: Kitiashvili IZ, Kireev VYu, Сhukarev SV, Kitiashvili DI, Salo AA, Timirbulatov II. Modern Possibilities of Safe Use of Dexmedetomidine in Premedication for Endoscopic Cholecystectomy. Intensive Care Herald. 2017;3:42–47. 


Study objective. To assess the clinical efficacy of dexmedetomidine as part of a premedication protocol for elective laparoscopic surgery. Study design. This was a prospective, comparative, randomized study. Materials and methods. Patients undergoing elective laparoscopic cholecystectomy (n = 70) were divided into two groups. In Group I (n = 32) patients were given dexmedetomidine as a 1-hour intravenous infusion (4.0 μg/mL; 1.0 μg/kg/h) before anesthesia induction. In Group II (n = 38) patients received diazepam (10 mg) as an intramuscular injection 30 minutes before anesthesia induction. The following clinical and laboratory parameters were monitored during the perioperative period: peripheral hemodynamics, respiratory rate, saturation levels, arterial blood gases and acid-base status, serum glucose and cortisol. Time to post-anesthesia recovery was also evaluated. Study results. Monitoring of the parameters of peripheral hemodynamics, saturation levels, glycemia, arterial blood gases and acid-base status did not reveal any significant differences between the groups. In Group I, the following parameters differed from those in Group II with a significance level p < 0.05: time to full emergence (4.1 ± 1.1 vs. 12.2 ± 1.2 min), frequency of nausea and vomiting (2.6 % vs. 37.5 %), and frequency of chills and shivering (5.3 % vs. 46.9 %). Conclusion. Premedication with infusion of dexmedetomidine has no effect on hemodynamics or gas exchange, pro- vides good protection from stress, and ensures earlier emergence than conventional premedication with diazepam.

Keywords: premedication, dexmedetomidine, diazepam

Received: 28.02.2017


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