New criteria for sepsis-induced coagulopathy. Review

S.V. Sinkov1,2, E.V. Roitman3, I.B. Zabolotskikh1,2

1 SBIHC “Regional Clinical Hospital № 2” MH KK, Krasnodar, Russia

2 FSBEI HE “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russia

3 RNRU named N.I. Pirogov Ministry of Health of Russia, Moscow, Russia

For correspondence: Sergey V. Sinkov — Doctor of Med. Sci., associate professor of the Department of Anesthesiology, Reanimatology and Transfusiology of the Kuban State Medical University, head of the Intensive Care Unit № 3 of Regional Clinical Hospital № 2; e-mail: ssinkov@yandex.ru

For citation: Sinkov SV, Roitman EV, Zabolotskikh IB. New criteria for sepsis-induced coagulopathy. Review. Annals of Critical Care. 2019;3:52–57.

DOI: 10.21320/1818-474X-2019-3-52-57


Abstract

In 2017 a new criteria for sepsis-induced coagulopathy (SIC) were issued following the revised sepsis definition in 2016. They aimed to the earliest detection of the sepsis-specific thrombotic phenotype of disseminated intravascular coagulation (DIC) in order to improve outcomes with early anticoagulant treatment in critically ill patients with sepsis. The following validation of SIC score demonstrated higher forecast value of that and revealed higher correlation with mortality compared to DIC score by the International Society on Thrombosis and Haemostasis (ISTH).

In the future the ISTH plans to offer a simplified two-step scoring system for early DIC syndrome revealing in which SIC scale is as the first step, and the next step is the assessing of overt-DIC in patients who meet the criteria of SIC. The main goal of that should become the opportunity of timely therapeutic effects to the hemocoagulation in order to improve the treatment effectiveness of a sepsis.

Keywords: sepsis-induced coagulopathy (SIC), sepsis, disseminated intravascular coagulation (DIC).

Received: 12.08.2019

Accepted: 03.09.2019


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