Whether free hemoglobin can be a severity’s marker of general condition of the patient with sepsis?

Y.P. Orlov1, 3, V.T. Dolgikh2, A.V. Glushchenko3

1 The Department of Anesthesiology and Intensive Care, Federal state budgetary educational institution higher education “Omsk State Medical University” Ministry of Health of Russian Federation, Omsk

2 The Department of Pathophysiology with course of clinical pathophysiology, Federal state budget educational institution higher education “Omsk State Medical University” Ministry of Health of Russian Federation, Omsk

3 BUZOO “City clinical emergency hospital N 1», Omsk, Russia

For correspondence: Orlov Yuriy Petrovich — MD, Professor of Anesthesiology and reanimatology, Russian “Omsk State Medical University” the Ministry of health of Russia; e-mail: orlov-up@mail.ru

For citation: Orlov YP, Dolgikh VT, Glushchenko AV. Whether Free Hemoglobin can be a Severity’s Marker of General Condition of the Patient with Sepsis? Alexander Saltanov Intensive Care Herald. 2018;1:48–54.

DOI: 10.21320/1818-474X-2018-1-48-54


Purpose of Research: to determine whether we can use free hemoglobin concentration as early prognostic marker and a predictor of mortality in sepsis. Materials and Methods. In a retrospective study in 60 patients aged 47,6 ± 7,2 years with sepsis (30,4 ± 2,1 points on the Mannheim’s scale for evaluation of the severity of peritonitis) modern methods of statistics (ROC-analysis) hypothesis was tested, whether level of free hemoglobin in the first 24 hours from the moment of admission can be used as a biomarker for diagnosis and prognosis for severe sepsis. Informative criterion was compared with the information of the procalcitonin test. Results. The present study had shown that the above average free hemoglobin concentration, measured on the first day of the heavy flow of sepsis, is directly connected with increased 30-days mortality, and the level of free hemoglobin in a first day of the disease has high sensitivity, specificity, and can determine the outcome of sepsis with accuracy up to 96,7 %. Conclusion. Free hemoglobin concentration above medium size identified on the first day of the currents of severe sepsis, is directly related to increased 30-day mortality, and researched level of free hemoglobin in day 1 of the disease has a high proportion of sensitivity and specificity. Level of free hemoglobin is Predictor outcome of sepsis in the first 24 hours after the start of therapy, but the results did not rule out the need to use the necessary test from septic patients, but rather the feasibility of combining the two dictates the criteria to assess the outcome of severe septic process that requires further research.

Keywords: free hemoglobin, procalcitonin, sepsis, ROC-analysis

Received: 15.01.2018


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