ISSN (print) 1726-9806     ISSN (online) 1818-474X
No. 2 (2022), FUNDAMENTAL ISSUES IN INTENSIVE CARE
No. 2 (2022)
FUNDAMENTAL ISSUES IN INTENSIVE CARE

Hyperoxia in the ICU and what has changed in 100 years in the tactics of using oxygen in medicine: a review

Published 29.04.2022
Yuriy P. Orlov
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-6747-998X
N.V. Govorova
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-0495-902X
V.N. Lukach
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-9440-3235
A.I. Kondratyev
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0001-9761-5957
E.N. Kakulya
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-2811-6051
A.V. Klementyev
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-7545-4782
G.A. Baytugaeva
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-6479-7915
A.V. Glushchenko
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-6690-9685
S.V. Tsilina
Omsk State Medical University, Omsk, Russia
https://orcid.org/0000-0002-6322-2095
I.A. Khilenko
GKB No. 11, Omsk, Russia
https://orcid.org/0000-0002-9666-4463
#2022-2
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Keywords

oxygen
hypoxia
hyperoxia
reactive oxygen species

How to Cite

1.
Orlov Y.P., Govorova N.V., Lukach V.N., Kondratyev A.I., Kakulya E.N., Klementyev A.V., Baytugaeva G.A., Glushchenko A.V., Tsilina S.V., Khilenko I.A. Hyperoxia in the ICU and what has changed in 100 years in the tactics of using oxygen in medicine: a review. Annals of Critical Care. 2022;(2):80-94. doi:10.21320/1818-474X-2022-2-80-94
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Abstract

INTRODUCTION. Oxygen, discovered in the XVIII century, is not only a necessary chemical element for the normal functioning of cells and the maintenance of life, but also an important component of the treatment of a wide range of critical conditions occurring with various variants of acute respiratory failure underlying the development of multiple organ failure. The use of oxygen in medicine is an indispensable tool in various critical situations. OBJECTIVES. To highlight in the review the predominantly toxic effects of oxygen, as well as existing data from experimental and fundamental studies on the potentiation role of hyperoxia in the processes of activation of free radical oxidation, leading to excessive synthesis of reactive oxygen species, which, in turn, are a leading factor in the pathogenesis of any critical condition always associated with hypoxia. MATERIALS AND METHODS. The review presents data from experimental studies, meta-analyses, randomized clinical trials that reflect the contribution of hyperoxia to the mortality rates of patients of intensive care units in a wide range of critical conditions. CONCLUSIONS. Maintaining tissue oxygenation by titrating oxygen concentrations to target pO2 and SpO2 levels against the background of constant monitoring of gas exchange parameters will avoid manifestations of toxic effects of oxygen (hyperoxia) in conditions of intensive care of critical conditions.

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