Keywords
preeclampsia
moderate proteinuria
severe proteinuria
pregnancy and childbirth outcome
moderate proteinuria
severe proteinuria
pregnancy and childbirth outcome
How to Cite
Pylaeva N.Y., Shifman E.M., Fedosov M.I., Pylaev I.A. The relationship of proteinuria detected on admission to the hospital on the outcome of pregnancy and childbirth in patients with preeclampsia. Article. Annals of Critical Care. 2019;(4):98–105. doi:10.21320/1818-474X-2019-4-98-105.
Statistic
Abstract Views: 34
PDF_2019-4_98-105 (Русский) Downloads: 6
HTML_2019-4_98-105 (Русский) Downloads: 14
PDF_2019-4_98-105 (Русский) Downloads: 6
HTML_2019-4_98-105 (Русский) Downloads: 14
Statistic from 21.01.2023
Language
Social Networks
Abstract
Background. Proteinuria is one of the most commonly diagnosed symptoms of gestational hypertensive disorders. Its values are important not only for the diagnosis of preeclampsia, but also correlate with a high probability of developing eclampsia, HELLP syndrome and unfavorable perinatal outcomes, and also indicate the development of kidney damage after delivery.
Objectives. To assess the relationship of proteinuria during pregnancy and childbirth for mother and fetus in patients with preeclampsia when admitted to hospital in the Republic of Crimea from 2014 to 2018.
Materials and methods. We performed a retrospective chart review of 149 patients with proteinuria in which pregnancy was complicated by preeclampsia. The study was conducted at admission of patients to hospital. According to the severity of proteinuria, the patients were divided into 2 groups — with moderate and severe proteinuria. The frequency of maternal and fetal complications, anthropometric indicators of mothers, their somatic diseases, and obstetric history were investigated as responses.
Results. Patients with severe proteinuria, registered at admission to the hospital, were characterized by a younger age and lower body mass index versus patients with moderate proteinuria. The presence of severe proteinuria versus moderate proteinuria was more often observed in primigravida and nulliparous. Obesity and kidney pathology were more common in the moderate proteinuria group and among patients with severe proteinuria, cardiovascular diseases. The risk of complications of preeclampsia, as well as the likelihood of prematurity and respiratory distress in newborns were higher in the group of patients with severe proteinuria.
Conclusions. The presence of severe proteinuria in patients with preeclampsia on admission to the hospital was characterized by a higher frequency of adverse outcomes for the mother and fetus than in the group with moderate proteinuria.
References
- Mol B.W.J., Roberts C.T., Thangaratinam S., et al. Pre-eclampsia. Lancet. 2016; 387(10022): 999–1011. DOI: 10.1016/S0140-6736(15)00070-7
- Tochio A., Obata S., Saigusa Y., Shindo R., et al. Does pre-eclampsia without proteinuria lead to different pregnancy outcomes than pre-eclampsia with proteinuria? J Obstet Gynaecol Res. 2019; Jul 1. DOI: 10.1111/jog.14017
- Özkara A., Kaya A.E., Başbuğ A., et al. Proteinuria in preeclampsia: is it important? Ginekol Pol. 2018; 89(5): 256–261. DOI: 10.5603/GP.a2018.0044
- Paula L.G., Pinheiro da Costa B.E., Hentschke M.R., et al. Increased proteinuria and uric acid levels are associated with eclamptic crisis. Pregnancy Hypertens. 2019; 15: 93–97. DOI: 10.1016/j.preghy.2018.12.003
- Dong X., Gou W., Li C., et al. Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes. Preg. Hyper. An Int. J. Women’s Card. Health. 2017; 8: 60–64. DOI: 10.1016/j.preghy.2017.03.005
- Анестезия, интенсивная терапия и реанимация в акушерстве и гинекологии. Клинические рекомендации. Протоколы лечения. Издание третье, дополненное и переработанное. Под ред. А.В. Куликова, Е.М. Шифмана. М.: Медицина; 2018. [Anesteziya, intensivnaya terapiya i reanimaciya v akusherstve i ginekologii. Klinicheskie rekomendacii. Protokoly lecheniya. Izdanie tret’e, dopolnennoe i pererabotannoe. Pod redakciej A.V. Kulikova, E.M. SHifmana. Moskow: Medicina, 2018. (In Russ)].
- Shifman E.M. Obesity is risk factor for developing preeclampsia in pregnant women. Proceedings of the 42nd annual meeting of the Society for Obstetric Anesthesia and Perinatology (SOAP). 2010; May 12–16, San Antonio, Texas, USA; Abstract 27.
- Маршалов Д., Шифман Е., Салов И. и др. Роль внутрибрюшной гипертензии в патогенезе акушерских и перинатальных осложнений. Врач. 2011; 2: 2–5. [Marshalov D., SHifman E., Salov I. i dr. Rol’ vnutribryushnoj gipertenzii v patogeneze akusherskih i perinatal’nyh oslozhnenij. Vrach. 2011; 2: 2–5. (In Russ)]
- Маршалов Д.В., Шифман Е.М., Салов И.А., Петренко А.П. Преэклампсия — синдром внутрибрюшной гипертензии беременных. Станет ли гипотеза теорией? Казанский мед. ж. 2016; 97(4): 638–644. DOI: 10.17750/KMJ2015-638. [Marshalov D.V., SHifman E.M., Salov I.A., Petrenko A.P. Preeklampsiya — sindrom vnutribryushnoj gipertenzii beremennyh. Stanet li gipoteza teoriej? Kazanskij med. zh. 2016; 97(4): 638–644. (In Russ)]
- Рымашевский А.Н., Туманян С.С., Франциянц Е.М., Туманян С.В. Эндокринная дисфункция у женщин с преэклампсией и алиментарным ожирением. Акушерство, гинекология и репродукция. 2017; 11(1): 14–18. DOI: 10.17749/2313-7347.2017.11.1.014-018. [Rymashevskij A.N., Tumanyan S.S., Franciyanc E.M., Tumanyan S.V. Endokrinnaya disfunkciya u zhenshchin s preeklampsiej i alimentarnym ozhireniem. Akusherstvo, ginekologiya i reprodukciya. 2017; 11(1): 14–18. (In Russ)]
- Вялкова А.А., Лебедева Е. Н., Афонина С.Н. и др. Заболевания почек и ожирение: молекулярные взаимосвязи и новые подходы к диагностике (обзор литературы). Нефрология. 2017; 21(3): 25–38.[Vyalkova A.A., Lebedeva E. N., Afonina S.N. i dr. Zabolevaniya pochek i ozhirenie: molekulyarnye vzaimosvyazi i novye podhody k diagnostike (obzor literatury). Nefrologiya. 2017; 21(3):25–38. (In Russ)]
- Marshalov D., Salov I., Petrenko A., et al. The interrelation between the renal blood flow and the severity of intra-abdominal hypertension in pregnancy. J. Perinat. Med. 2013;(41): 56. DOI: 10.1515/jpm-2013–2003.P.56
- Шифман Е.М., Тихова Г.П., Флока С.Е. Клинико-физиологические особенности развития неврологических осложнений эклампсии: систематический обзор. Акушерство и гинекология. 2010; 5: 6–15.[Shifman E.M., Tihova G.P., Floka S.E. Kliniko-fiziologicheskie osobennosti razvitiya nevrologicheskih oslozhnenij eklampsii: sistematicheskij obzor. Akusherstvo i ginekologiya. 2010; 5: 6–15. (In Russ)]
- Шифман Е.М., Тихова Г.П., Флока С.Е., Акимова Д.М. Клинико-лабораторные исследования у больных с неврологическими осложнениями эклампсии. Акушерство и гинекология. 2012; 2: 4–10.[Shifman E.M., Tihova G.P., Floka S.E., Akimova D.M. Kliniko-laboratornye issledovaniya u bol’nyh s nevrologicheskimi oslozhneniyami eklampsii. Akusherstvo i ginekologiya. 2012; 2: 4–10. (In Russ)]
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.