Perioperative iron deficiency anemia in obstetrics. Possibilities of prevention and correction. Review
Issue 4 (2020) , INTENSIVE CARE IN OBSTETRICS
Issue 4 (2020)
INTENSIVE CARE IN OBSTETRICS

Perioperative iron deficiency anemia in obstetrics. Possibilities of prevention and correction. Review

https://doi.org/10.21320/1818-474X-2020-4-99-107
Published 16.11.2020
Alexander V. Kulikov
Ural state medical university, Yekaterinburg, Russia
https://orcid.org/0000-0002-7768-4514
E.M. Shifman
Moscow Regional Research Clinical Institute, Moscow, Russia
https://orcid.org/0000-0002-6113-8498
A.A. Matkovsky
Regional children’s hospital, Yekaterinburg, Russia
https://orcid.org/0000-0002-2920-917X
A.V. Kayumova
Regional children’s hospital, Yekaterinburg, Russia
https://orcid.org/0000-0003-2685-4285
A.M. Ronenson
https://orcid.org/0000-0002-2468-297X
#2020-4
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Keywords

blood management
obstetrics
iron deficiency
iron deficiency anemia
pregnancy
intravenous iron

How to Cite

Kulikov A.V., Shifman E.M., Matkovsky A.A., Kayumova A.V., Ronenson A.M. Perioperative iron deficiency anemia in obstetrics. Possibilities of prevention and correction. Review. Annals of Critical Care. 2020;(4):99–107. doi:10.21320/1818-474X-2020-4-99-107.
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Abstract

In the review diagnostics and correction of iron deficiency anemia (IDA) is considered during pregnancy and in the perioperative period within the concept of “patient blood management”. Features of diagnosis of anemia and verification of an iron deficiency (ID) are discussed during pregnancy, correction stages with use of oral and intravenous iron, transfusion erythrocytes and reinfusion of blood. Data on advantage of intravenous iron to correction of ID and IDA are provided during pregnancy and in the perioperative period.
https://doi.org/10.21320/1818-474X-2020-4-99-107
PDF_2020-04_99-107 (Русский)
HTML_2020-04_99-107 (Русский)

References

  1. World Health Organization — IDA. Available from: https://www.who.int/nutrition/topics/ida/en/ (accessed 29.06.2020).
  2. Muñoz M., Acheson A.G., Bisbe E., et al. An international consensus statement on the management of postoperative anaemia after major surgical procedures. Anaesthesia. 2018; 73(11): 1418–1431. DOI: 10.1111/anae.14358
  3. Warner M.A., Shore-Lesserson L., Shander A., et al. Perioperative Anemia: Prevention, Diagnosis, and Management Throughout the Spectrum of Perioperative Care. Anesth Analg. 2020; 130(5): 1364–1380.
  4. Meybohm P., Neef V., Westphal S., et al. Preoperative iron deficiency with/without anemia-an underestimated risk factor? Chirurg. 2020; 91(2): 109–114.
  5. Lasocki S., Pène F., Ait-Oufella H., et al. Management and prevention of anemia (acute bleeding excluded) in adult critical care patients. Anaesth Crit Care Pain Med. 2020; S2352–5568(20)30070-9. DOI: 10.1016/j.accpm.2020.04.004
  6. American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology. 2015; 122(2): 241–275.
  7. Mueller M.M., Van Remoortel H., Meybohm P., et al. Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference. JAMA. 2019; 321(10): 983–9.
  8. Casans Francés R., Ripollés Melchor J., Calvo Vecino J.M.; Grupo Español de Rehabilitación Multimodal GERM/ERAS-Spain. Is it time to integrate patient blood management in ERAS guidelines? Rev Esp Anestesiol Reanim. 2015; 62(2): 61–63. DOI: 10.1016/j.redar.2014.12.005
  9. Wilson R.D., Caughey A.B., Wood S.L., et al. Guidelines for Antenatal and Preoperative care in Cesarean Delivery: Enhanced Recovery After Surgery Society Recommendations (Part 1). Am J Obstet Gynecol. 2018; 219(6): 523.e1–523.e15. DOI: 10.1016/j.ajog.2018.09.015
  10. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/NMH/NHD/MNM/11.1) Available from: http://www.who.int/vmnis/indicators/haemoglobin.pdf (accessed 15.10.2020).
  11. Pavord S., Myers B., Robinson S., et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2012; 156(5): 588–600. DOI: 10.1111/j.1365-2141.2011.09012.x.
  12. Aguree S., Gernand A.D. Plasma volume expansion across healthy pregnancy: a systematic review and meta-analysis of longitudinal studies. BMC Pregnancy Childbirth. 2019; 19(1): 508. DOI: 10.1186/s12884-019-2619-6
  13. Means R.T. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients. 2020; 12(2): 447. DOI: 10.3390/nu12020447
  14. Guignard J., Deneux-Tharaux C., Seco A., et al. EPIMOMS group. Gestational anaemia and severe acute maternal morbidity: a population-based study. Anaesthesia. 2020; Aug 26. DOI: 10.1111/anae.15222
  15. Smith C., Teng F., Branch E., et al. Maternal and Perinatal Morbidity and Mortality Associated with Anemia in Pregnancy. Obstet Gynecol. 2019; 134(6): 1234–1244. DOI: 10.1097/AOG.0000000000003557
  16. Ray J.G., Davidson A., Berger H., et al. Haemoglobin levels in early pregnancy and severe maternal morbidity: population-based cohort study. BJOG. 2020; Mar 16.
  17. Vander Meulen H., Strauss R., Lin Y., et al. The contribution of iron deficiency to the risk of peripartum transfusion: a retrospective case control study BMC Pregnancy Childbirth. 2020; 20(1): 196. DOI: 10.1186/s12884-020-02886-z
  18. Ferguson M.T., Dennis A.T. Defining peri-operative anaemia in pregnant women — challenging the status quo. Anaesthesia. 2019; 74(2): 237–245. DOI: 10.1111/anae.14468
  19. Aparicio E., Jardí C., Bedmar C., et al. Nutrient Intake during Pregnancy and Post-Partum: ECLIPSES Study. Nutrients. 2020; 12(5): E1325. DOI: 10.3390/nu12051325
  20. Milman N.T. Dietary Iron Intake in Pregnant Women in Europe: A Review of 24 Studies from 14 Countries in the Period 1991–2014. J Nutr Metab. 2020 Feb 24; 2020: 7102190. DOI: 10.1155/2020/7102190
  21. Fisher A.L., Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017; 106(Suppl 6): 1567S–1574S.
  22. Muñoz M., Peña-Rosas J.P., Robinson S., et al. Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Transfus Med. 2018; 28(1): 22–39.
  23. Georgieff M.K. Iron deficiency in pregnancy. Am J Obstet Gynecol. 2020; S0002–9378(20)30328–8. DOI: 10.1016/j.ajog.2020.03.006
  24. Dewey K.G., Oaks B.M. U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation. Am J Clin Nutr. 2017; 106(Suppl 6): 1694S–1702S. DOI: 10.3945/ajcn.117.156075
  25. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations [Internet]. Available from: https://www.who.int/publications-detail/9789240000124 (accessed 21.05.2020).
  26. Auerbach M., Adamson J.W. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016; 91(1): 31–38. DOI: 10.1002/ajh.24201
  27. Cappellini M.D., Comin-Colet J., de Francisco A., et al. Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management. Am J Hematol. 2017; 92(10): 1068–1078.
  28. Zdanowicz J.A., Surbek D. Patient blood management in obstetrics — Review. Transfus Apher Sci. 2019 Aug; 58(4): 412–415.
  29. Shaylor R., Weiniger C.F., Austin N., et al. National and International Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017; 124(1): 216–232. DOI: 10.1213/ANE.0000000000001473
  30. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. Geneva: World Health Organization, 2016.
  31. Tran K., McCormack S. Screening and Treatment of Obstetric Anemia: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health, 2019.
  32. Guideline: Daily Iron Supplementation in Adult Women and Adolescent Girls. Geneva: World Health Organization, 2016. Available from: https://www.who.int/nutrition/publications/micronutrients/guidelines/daily_iron_supp_womenandgirls.pdf?ua = 1 (accessed 15.10.2020).
  33. Kuruvilla S., Bustreo F., Kuo T., et al. The Global strategy for women’s, children’s and adolescents’ health (2016–2030): a roadmap based on evidence and country experience. Bull World Health Organ. 2016; 94(5): 398–400. DOI: 10.2471/BLT.16.170431
  34. Schaefer B., Meindl E., Wagner S., et al. Intravenous iron supplementation therapy. Mol Aspects Med. 2020; 100862. DOI: 10.1016/j.mam.2020.100862
  35. Qassim A., Grivell R.M., Henry A., et al. Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta-analysis. Med J Aust. 2019; 211(8): 367–373.
  36. Lewkowitz A.K., Gupta A., Simon L., et al. Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis. J Perinatol. 2019; 39(4): 519–532.
  37. Govindappagari S., Burwick R.M. Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. Am J Perinatol. 2019; 36(4): 366–376.
  38. Auerbach M., Gafter-Gvili A., Macdougall I.C. Intravenous iron: a framework for changing the management of iron deficiency. Lancet Haematol. 2020; 7(4): e342–e350. DOI: 10.1016/S2352-3026(19)30264-9
  39. Приложение № 1 к распоряжению Правительства Российской Федерации от 12 октября 2019 года N 2406-р «Перечень жизненно необходимых и важнейших лекарственных препаратов для медицинского применения на 2020 год» [Электронный ресурс]. Режим доступа: https://base.garant.ru/72861778/53f89421bbdaf741eb2d1ecc4ddb4c33. Ссылка активна на 15.10.2020. [Prilozhenie № 1 k rasporyazheniyu Pravitel’stva Rossijskoj Federacii ot 12 oktyabrya 2019 goda N 2406-r “Perechen’ zhiznenno neobhodimyh i vazhnejshih lekarstvennyh preparatov dlya medicinskogo primeneniya na 2020 god” [Elektronnyj resurs]. Available from: https://base.garant.ru/72861778/53f89421bbdaf741eb2d1ecc4ddb4c33/ (accessed 15.10.2020). (In Russ)]
  40. Jose A., Mahey R., Sharma J.B., et al. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy-randomised controlled trial. BMC Pregnancy Childbirth. 2019; 19(1): 54. DOI: 10.1186/s12884-019-2200-3
  41. Khalafallah A.A., Hyppa A., Chuang A., et al. A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy. Semin Hematol. 2018; 55(4): 223–234. DOI: 10.1053/j.seminhematol.2018.04.006
  42. Wani S., Noushad M., Ashiq S. REGAIN STUDY: Retrospective Study to Assess the Effectiveness, Tolerability, and Safety of Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnant Women. Anemia. 2019: 4640635. DOI: 10.1155/2019/4640635
  43. Froessler B., Gajic T., Dekker G., Hodyl N.A. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018; 298(1): 75–82.
  44. Daniilidis A., Panteleris N., Vlachaki E., Breymann C., Assimakopoulos E. Safety and efficacy of intravenous iron administration for uterine bleeding or postpartum anaemia: a narrative review. J Obstet Gynaecol. 2018; 38(4): 443–447.
  45. Breymann C., Honegger C., Hösli I., Surbek D. Diagnosis and treatment of iron-deficiency anaemia in pregnancy and postpartum. Arch Gynecol Obstet. 2017; 296(6): 1229–1234.
  46. Wesström J. Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet. 2020; 301(5): 1127–1131. DOI: 10.1007/s00404-020-05509-2
  47. Iyoke C.A., Emegoakor F.C., Ezugwu E.C., et al. Effect of treatment with single total-dose intravenous iron versus daily oral iron(III)-hydroxide polymaltose on moderate puerperal iron-deficiency anemia. Ther Clin Risk Manag. 2017; 13: 647–653. DOI: 10.2147/TCRM.S112227
  48. Holm C., Thomsen L.L., Langhoff-Roos J. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage. J Matern Fetal Neonatal Med. 2019; 32(17): 2797–2804. DOI: 10.1080/14767058.2018.1449205
  49. Shi Q., Leng W., Wazir R., et al. Intravenous Iron Sucrose versus Oral Iron in the Treatment of Pregnancy with Iron Deficiency Anaemia: A Systematic Review. Gynecol Obstet Invest. 2015; 80(3): 170–178. DOI: 10.1159/000376577
  50. Bhavi S.B., Jaju P.B. Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial. BMC Pregnancy Childbirth. 2017; 17(1): 137. DOI: 10.1186/s12884-017-1313-9
  51. Neogi S.B., Devasenapathy N., Singh R., et al. Safety and effectiveness of intravenous iron sucrose versus standard oral iron therapy in pregnant women with moderate-to-severe anaemia in India: a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Glob Health. 2019; 7(12): e1706–e1716. DOI: 10.1016/S2214-109X(19)30427-9
  52. Guideline: Iron Supplementation in Postpartum Women. Geneva: World Health Organization, 2016 [Internet]. Available from: https://apps.who.int/iris/handle/10665/249242 (accessed 15.10.2020).
  53. Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017; 130(4): e168–e186. DOI: 10.1097/AOG.0000000000002351
  54. Shaji Geetha N., Bobby Z., Dorairajan G., Jacob S.E. Increased hepcidin levels in preeclampsia: a protective mechanism against iron overload mediated oxidative stress? J Matern Fetal Neonatal Med. 2020; 1–6. DOI: 10.1080/14767058.2020.1730322
  55. Mannaerts D., Faes E., Cos P., et al. Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PLoS One. 2018; 13(9): e0202919. DOI: 10.1371/journal.pone.0202919
  56. Silva J.V.F., Ferreira R.C., Tenório M.B., et al. Hyperferritinemia worsens the perinatal outcomes of conceptions of pregnancies with preeclampsia. Pregnancy Hypertens. 2020; 19: 233–238. DOI: 10.1016/j.preghy.2019.11.004
  57. Goucher H., Wong C.A., Patel S.K., Toledo P. Cell Salvage in Obstetrics. Anesth Analg. 2015; 121(2): 465–468. DOI: 10.1213/ANE.0000000000000786
  58. Sullivan I.J., Ralph C.J. Obstetric intra-operative cell salvage: a review of an established cell salvage service with 1170 re-infused cases. Anaesthesia. 2019; 74(8): 976–983. DOI: 10.1111/anae.14630
  59. Pacheco L.D., Gei A.F. Controversies in the management of placenta accreta. Obstet Gynecol Clin North Am. 2011; 38(2): 313-xi. DOI: 10.1016/j.ogc.2011.02.018
  60. Royal College of Obstetricians and Gynaecologists Blood Transfusion in Obstetrics Green-top Guideline. 2015 May; 47: 23.
  61. Sentilhes L., Vayssière C., Deneux-Tharaux C., et al. Postpartum hemorrhage: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF): in collaboration with the French Society of Anesthesiology and Intensive Care (SFAR). Eur J Obstet Gynecol Reprod Biol. 2016; 198: 12–21. DOI: 10.1016/j.ejogrb.2015.12.012
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