Correlation between thrombodynamics test levels and the incidence of venous thromboembolic complications in prostate cancer patients undergone radical prostatectomy. Retrospective study
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Keywords

thrombosis
prostate cancer
prostatectomy

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Suvorin PA, Khoronenko VE, Smirnova TY, Alexandrova EA Correlation between thrombodynamics test levels and the incidence of venous thromboembolic complications in prostate cancer patients undergone radical prostatectomy. Retrospective study. Annals of Critical Care. 2021;(1):134–142. doi:10.21320/1818-474X-2021-1-134-142.

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Abstract

Introduction. According to international studies, the frequency of venous thromboembolism (VTE), in cancer patients, is between 5–7 %. The presence of VTE in cancer patients during the oncological treatment increases the risk of lethal outcome. The pelvic cavity, especially in patients with cancer of the prostate gland, represents one of the main thrombogenic localizations. This problem remains actual despite the implementation of modern techniques of VTE prophylaxis and laboratory control of the hemostatic system.

Objectives. to assess the correlation between thrombodynamics test levels and the frequency of VTE complications in prostate cancer patients after surgical treatment.

Materials and methods. 59 patients undergoing radical prostatectomy with or without lymphadenectomy were included in the study. Preoperative assessment included standard laboratory investigations and an ultrasound examination to exclude deep vein thrombosis in lower extremities. To calculate the risk of VTE, Caprini score was used. Pharmacological prophylaxis of VTE was performed according to the ASCO clinical recommendations with low molecular weight heparin (LMWH), the dose was selected out of the patient weight. In the early postoperative period, standard coagulation tests were performed at 3 control points with the determination of D-dimer and the thrombodynamics test. Ultrasound monitoring of lower extremities was performed on the 3rd day after surgery and the day before discharge.

Results. The incidence of VTE in the early postoperative period was found as 5 %. Using the thrombodynamics test we’ve revealed that if the steady-state rate of clot growth rises above 43 μm/min before administration or at the peak of LMWH action in the first 3 days after surgery, the risk of thrombosis increases significantly.

Conclusion. The steady-state clot growth rate exceeding 43 μm/min can be used as a criterion for an increased risk of VTE in patients undergone radical prostatectomy.

https://doi.org/10.21320/1818-474X-2021-1-134-142
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References

  1. Никулина Н.Н., Тереховская Ю.В. Эпидемиология тромбоэмболии легочной артерии в современном мире: анализ заболеваемости, смертности и проблем их изучения. Российский кардиологический журнал. 2019;(6): 103–108. DOI: 10.15829/1560-4071-2019-6-103-108 [Nikulina N., Terekhovskaya Y. Epidemiology of pulmonary embolism in today’s context: analysis of incidence, mortality and problems of their study. Russian Journal of Cardiology. 2019; 6: 103– (In Russ.)]
  2. Российский статистический ежегодник. 2019. Стат.сб./Росстат. Р М., 2019. [Russian Statistical Yearbook. 2019: Stat. book/ Rosstat. R76. Мoscow, 2019. (In Russ)]
  3. Karimi M., Cohan N. Cancer-associated thrombosis. Open Cardiovasc Med J. 2010; 4(2): 78–82. DOI: 10.2174/1874192401004020078
  4. Amer M. Cancer-associated thrombosis: clinical presentation and survival. Cancer Manag Res. 2013: 165. DOI: 10.2147/CMAR.S47094
  5. Noble S., Pasi J. Epidemiology and pathophysiology of cancer-associated thrombosis. Br J Cancer. 2010; 102(S1): S2– DOI: 10.1038/sj.bjc.6605599
  6. Суворин П.А., Хороненко В.Э., Жарков П.А. идр. Профилактика венозных тромбоэмболий у онкологических больных. Онкология. Журнал им. П.А. Герцена. 2017; 6(1): 71–75. DOI: 17116/onkolog20176171-75 [Suvorin P., Khoronenko V., Zharkov P., et al. Prevention of venous thromboembolism in cancer patients. Onkologiya Zhurnal imeni PAGertsena. 2017; 6(1): 71–75. (In Russ)]
  7. Garcia D., Baglin T., Weitz J., et al. Parenteral anticoagulants. Chest. 2012; 141(2): e24S–e43S. DOI: 10.1378/chest.11-2291
  8. Wang Z., Li J., Cao Q., et al. Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer. Clinical and Applied Thrombosis/Hemostasis. 2017; 24(5): 755–763. DOI: 10.1177/1076029617724229
  9. Halaby R., Popma C., Cohen A., et al. D-Dimer elevation and adverse outcomes. J Thromb Thrombolysis. 2014; 39(1): 55–59. DOI: 10.1007/s11239-014-1101-6
  10. Yu J., Li D., Lei D., et al. Tumor-Specific D-Dimer Concentration Ranges and Influencing Factors: A Cross-Sectional Study. PLoS One. 2016; 11(11): e0165390. DOI: 10.1371/journal.pone.0165390
  11. Lippi G., Bonfanti L., Saccenti C., et al. Causes of elevated D-dimer in patients admitted to a large urban emergency department. Eur J Intern Med. 2014; 25(1): 45–48. DOI: 10.1016/j.ejim.2013.07.012
  12. Olson J., Cunningham M., Higgins R., et al. D-dimer: Simple Test, Tough Problems. Arch Pathol Lab Med. 2013; 137(8): 1030–1038. DOI: 10.5858/arpa.2012-0296-CP
  13. Brunetti L., Wassef A., Sadek R., et al. Anticoagulant activity of enoxaparin and unfractionated heparin for venous thromboembolism prophylaxis in obese patients undergoing sleeve gastrectomy. Surgery for Obesity Related Diseases. 2019; 15(3): 363–373. DOI: 10.1016/j.soard.2018.12.014
  14. Rostas J., Brevard S., Ahmed N., et al. Standard Dosing of Enoxaparin for Venous Thromboembolism Prophylaxis Is Not Sufficient for Most Patients Within a Trauma Intensive Care Unit. Am Surg. 2015; 81(9): 889–892. DOI: 10.1177/000313481508100923
  15. Nunez J., Becher R., Rebo G., et al. Prospective Evaluation of Weight-Based Prophylactic Enoxaparin Dosing in Critically Ill Trauma Patients: Adequacy of AntiXa Levels Is Improved. Am Surg. 2015; 81(6): 605–609. DOI: 10.1177/000313481508100625
  16. Davies N., Harrison N., Sabra A., et al. Application of ROTEM to assess hypercoagulability in patients with lung cancer. Thromb Res. 2015; 135(6): 1075–1080. DOI: 10.1016/j.thromres.2015.03.021
  17. Баландина А.Н., Кольцова Е.М., Шибеко А.М. идр. Тромбодинамика: новый подход к диагностике нарушений системы гемостаза. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2018; 17(4): 114–126. DOI: 24287/1726-1708-2018-17-4-114-126 [Balandina A.N., Koltsova E.M., Shibeko A.M., et al. Thrombodynamics: a new method to the diagnosis of hemostasis system disorders. Pediatric Hematology/Oncology and Immunopathology. 2018; 17(4): 114–126. (In Russ)]
  18. Буянова С.Н., Будыкина Т.С., Сибряева В.А. идр. Оценка эффективности теста тромбодинамики в диагностике нарушений системы гемостаза у хирургических гинекологических больных с высоким риском развития венозных тромбоэмболических осложнений. Российский вестник акушера-гинеколога. 2017; 17(5): 65–70. DOI: 10.17116/rosakush201717565-70 [Buyanova S., Budykina T., Sibryaeva V., et al. Evaluating the efficiency of thrombodynamics test in the diagnosis of hemostatic system disorders in gynecologic surgical patients at high risk for venous thromboembolic events. Rossiiskii vestnik akushera-ginekologa. 2017; 17(5): 65. (In Russ)]
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