Рандомизированное двойное слепое плацебо-контролируемое исследование ингаляций ксенона в терапии хронической боли в онкологии

G. R. Abuzarova; V. E. Khoronenko; Regina R. Sarmanayeva; S. V. Kuznetcov

doi:10.21320/1818-474X-2020-4-48-57

Issue 4 (2020) , PAIN MANAGEMENT

Issue 4 (2020)

PAIN MANAGEMENT

Double-blind, randomized, placebo-controlled study of Xenon in cancer pain therapy

https://doi.org/10.21320/1818-474X-2020-4-48-57

Published 16.11.2020

G.R. Abuzarova⁺⁻
V.E. Khoronenko⁺⁻
Regina R. Sarmanayeva⁺⁻
S.V. Kuznetcov⁺⁻

G.R. Abuzarova

P.A. Hertsen Moscow Oncology Research Center — branch of the National Medical Research Radiological Center, Moscow, Russia

https://orcid.org/0000-0002-6146-2706

V.E. Khoronenko

P.A. Hertsen Moscow Oncology Research Center — branch of the National Medical Research Radiological Center, Moscow, Russia

https://orcid.org/0000-0001-8845-9913

Regina R. Sarmanayeva

P.A. Hertsen Moscow Oncology Research Center — branch of the National Medical Research Radiological Center, Moscow, Russia

https://orcid.org/0000-0002-0727-5758

S.V. Kuznetcov

P.A. Hertsen Moscow Oncology Research Center — branch of the National Medical Research Radiological Center, Moscow, Russia

https://orcid.org/0000-0001-5317-0394

PDF_2020-04_48-57 (Русский)

HTML_2020-04_48-57 (Русский)

Keywords

Cancer Pain
Xenon
Double-blind
Placebo-controlled study
Pain Management

How to Cite

Abuzarova G.R., Khoronenko V.E., Sarmanayeva R.R., Kuznetcov S.V. Double-blind, randomized, placebo-controlled study of Xenon in cancer pain therapy. Annals of Critical Care. 2020;(4):48–57. doi:10.21320/1818-474X-2020-4-48-57.

Statistic

Abstract Views: 88
PDF_2020-04_48-57 (Русский) Downloads: 12
HTML_2020-04_48-57 (Русский) Downloads: 4

Statistic from 21.01.2023

Abstract

Objectives. To evaluate safety and efficacy of administering a 50/50 mixture of xenon and oxygen gases to patients with moderate-to-severe cancer pain.

Materials and methods. The study included 131 patients with moderate-to-severe cancer pain, who had been randomized into two groups: patients to receive inhalation of a mixture of xenon and oxygen in a volume ratio of 50/50, and those to receive inhalation of a mixture of oxygen and air. Efficacy was evaluated based on the following measurements: intensity of pain by NRS 30 minutes after each procedure; at the end of treatment; 2 weeks after treatment. Safety was assessed by dynamics of hemodynamic and laboratory parameters; incidence of adverse events in each group.

Results. The study results showed that the median decrease in pain intensity measured by NRS 30 minutes after inhalation of xenon-oxygen mixture was –19.00 (–24.50 to 13.25) against –4.00 (–6.00 to 2.00) in the placebo group: the results attested to statistically significant differences (p < 0.001) and a superior analgesic efficacy of xenon-oxygen mixture over placebo. Following the course of treatment, a significant NRS-measured decrease from 50.00 (40.00–60.00) to 30.00 (20.00–41.25) mm was registered in the active treatment group compared to an unverifiable decrease in NRS from 60.00 (35,00–70.00) to 55.0 (35.00–60.00) mm in the placebo group. The course of xenon inhalations made it possible to significantly reduce average daily doses of tramadol from 210.9 ± 31.3 mg to 150.1 ± 28.3, and also significantly reduce NSAID intake. AEs (n = 8) were observed only in 7 patients in the group receiving xenon therapy. Аll AEs were mild.

Conclusions. Xenon-oxygen mixture was safe and performed better than placebo for analgesia in cancer pain treatment.

https://doi.org/10.21320/1818-474X-2020-4-48-57

PDF_2020-04_48-57 (Русский)

HTML_2020-04_48-57 (Русский)

References

Reddy A., Yennurajalingam S., et al. Frequency, outcome, and predictors of success within 6 weeks of an opioid rotation among outpatients with cancer receiving strong opioids. Oncologist. 2013; 18: 212–220. DOI: 10.1634/theoncologist.2012-0269
Corli O., Roberto A., Corsi N., Galli F., Pizzuto M. Opioid switching and variability in response in pain cancer patients. Supportive Care Cancer. 2019; 27(6): 2321–2327. DOI: 10.1007/s00520-018-4485-6
Schuster M., Bayer O., Heid F., Laufenberg-Feldmann R. Opioid Rotation in Cancer Pain Treatment. Deutsches Aerzteblatt Int. 2018; 115(9): 135–142. DOI: 10.3238/arztebl.2018.0135
Fallon M.T., Wilcock A., Kelly C.A. Oral Ketamine vs Placebo in Patients with Cancer-Related Neuropathic Pain. JAMA Oncology. 2018; 4(6): 870–872. DOI: 10.1001/jamaoncol.2018.0131
Brockett-Walker C. The Use of Ketamine as an Adjunct to Treating Opioid Refractory Cancer-Related Pain in the Emergency Department. Adv Emerg Nurs J. 2019; 41(2): 101–106. DOI: 10.1097/tme.0000000000000244
Буров Н.Е., Николаев Л.Л., Потапов В.Н., Козлов С.М., Коробов А.В., Потапов С.В. Технические, экономические и анестезиологические основы рециклинга медицинского ксенона. Клиническая анестезиология и реаниматология. 2008; 5(3): 32–9. [Burov N.E., Nikolaev L.L., Potapov V N., Kozlov S.M., Korobov A.V., Potapov S.V. Tekhnicheskie, ekonomicheskie i anesteziologicheskie osnovy reciklinga medicinskogo ksenona. Klinicheskaya anesteziologiya i reanimatologiya. 2008; 5(3): 32–9. (In Russ)]
Кукушкин М.Л. и др. Обезболивающее действие ксенона у крыс на модели воспалительной боли. Бюллетень экспериментальной биологии и медицины. 2016; 161(10): 445–447. [Kukushkin M.L., et al. Obezbolivayushchee dejstvie ksenona u krys na modeli vospalitel’noj boli. Byulleten’ eksperimental’noj biologii i mediciny. 2016; 161(10): 445–447. (In Russ)]
Holsträter T.F., Georgieff M., Föhr K.J., et al. Intranasal application of xenon reduces opioid requirement and postoperative pain in patients undergoing major abdominal surgery: a randomized controlled trial. Anesthesiology. 2011; 115(2): 398–407. DOI: 10.1097/ALN.0b013e318225cee5
Winkler D.A., Thornton A., Farjot G., Katz I. The diverse biological properties of the chemically inert noble gases. Pharmacology Therapeutics. 2016; 160: 44–64. DOI: 10.1016/j.pharmthera.2016.02.002
Arola O., Saraste A., Laitio R., et al. Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. J Am Coll Cardiol. 2017; 70(21): 2652–2660. DOI: 10.1016/j.jacc.2017.09.1088
Weber N.C., Frässdorf J., Ratajczak C., et al. Xenon induces late cardiac preconditioning in vivo: a role forcyclooxygenase 2? Anesthesia Analgesia. 2008; 107(6): 1807–13. DOI: 10.1213/ane.Ob013e31818874bf
Mio Y., Shim Y.H., Richards E., Bosnjak Z.J., Pagel P.S., Bienengraeber M. Xenon preconditioning: the role of prosurvival signaling, mitochondrial permeability transition and bioenergetics in rats. Anesthesia Analgesia. 2009; 108(3): 858–66. DOI: 10.1213/ane.0b013e318192a520

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Most read articles by the same author(s)

Aleksey M. Ovechkin, A.Zh. Bayalieva, A.A. Ezhevskaya, A.A. Eremenko, D.V. Zabolotskij, I.B. Zabolotskikh, A.E. Karelov, V.A. Koryachkin, A.P. Spasova, V.E. Khoronenko, D.N. Uvarov, G.E. Ulrikh, R.V. Shadrin, Postoperative analgesia. Guidelines , Annals of Critical Care: Issue 4 (2019)
Igor B. Zabolotskikh, M.Yu. Kirov, K.M. Lebedinskii, D.N. Protsenko, S.N. Avdeev, A.A. Andreenko, L.V. Arsentyev, V.S. Afonchikov, I.I. Afukov, A.A. Belkin, E.A. Boeva, A.Yu. Bulanov, Ya.I. Vasiliev, A.V. Vlasenko, V.I. Gorbachev, E.V. Grigor’ev, S.V. Grigor’ev, A.I. Gritsan, A.A. Eremenko, E.N. Ershov, M.N. Zamyatin, G.E. Ivanova, A.N. Kuzovlev, A.V. Kulikov, R.E. Lakhin, I.N. Leiderman, A.I. Lenkin, V.A. Mazurok, T.S. Musaeva, E.M. Nikolaenko, Yu.P. Orlov, S.S. Petrikov, E.V. Roitman, A.M. Ronenson, A.A. Smetkin, A.A. Sokolov, S.M. Stepanenko, V.V. Subbotin, N.D. Ushakova, V.E. Khoronenko, S.V. Tsarenko, E.M. Shifman, D.L. Shukevich, A.V. Shchegolev, A.I. Yaroshetskiy, M.B. Yarustovsky, Anesthesia and intensive care for patients with COVID-19. Russian Federation of anesthesiologists and reanimatologists guidelines , Annals of Critical Care: Issue 1-S (2021): Supplement
Igor B. Zabolotskikh, A.A. Belkin, E.V. Grigoryev, S.V. Grigoryev, A.I. Gritsan, P.V. Dunts, V.I. Ershov, M.Yu. Kirov, A.N. Kuzovlev, A.V. Kulikov, T.S. Musaeva, A.M. Ovezov, D.N. Protsenko, V.V. Subbotin, N.V. Trembach, V.E. Khoronenko, E.M. Shifman, A.V. Shchegolev, K.M. Lebedinskii, Russian registry of Surgical OutcomeS — RuSOS: study protocol , Annals of Critical Care: Issue 1 (2024)
Igor B. Zabolotskikh, N.V. Trembach, M.A. Magomedov, A.S. Popov, Yu.P. Malyshev, A.A. Dmitriev, E.V. Grigoryev, V.V. Fisher, V.E. Khoronenko, V.N. Kokhno, A.P. Spasova, V.R. Davydova, A.I. Gritsan, K.M. Lebedinskii, P.V. Dunts, A.Zh. Bayalieva, A.M. Ovezov, D.V. Martynov, N.G. Arikan, M.Yu. Kirov, V.I. Ershov, I.N. Pasechnik, A.N. Kuzovlev, D.E. Fedunets, Structure and frequency of comorbidities and associated postoperative complications: a national observational multicenter study STOPRISK , Annals of Critical Care: Issue 3 (2023)
Igor B. Zabolotskikh, A.E. Bautin, E.V. Grigoryev, A.I. Gritsan, K.M. Lebedinskii, V.I. Potievskaya, V.A. Rudnov, V.V. Subbotin, V.E. Khoronenko, R.V. Shadrin, Perioperative management of patients with hypertension. Guidelines , Annals of Critical Care: Issue 2 (2020)
V.E. Khoronenko, D.S. Baskakov, Anna S. Malanova, E.A. Mandryka, M.M. Shemetova, Post-thoracotomy pain syndrome as a risk factor for the development of nosocomial pneumonia , Annals of Critical Care: Issue 1 (2019)
Igor B. Zabolotskikh, M.Yu. Kirov, K.M. Lebedinskii, D.N. Protsenko, S.N. Avdeev, A.A. Andreenko, L.V. Arsentyev, V.S. Afonchikov, I.I. Afukov, A.A. Belkin, E.A. Boeva, A.Yu. Bulanov, Ya.I. Vasiliev, A.V. Vlasenko, V.I. Gorbachev, E.V. Grigor’ev, S.V. Grigor’ev, A.I. Gritsan, A.A. Eremenko, E.N. Ershov, M.N. Zamyatin, A.N. Kuzovlev, A.V. Kulikov, R.E. Lakhin, I.N. Leiderman, A.I. Lenkin, V.A. Mazurok, T.S. Musaeva, E.M. Nikolaenko, Yu.P. Orlov, S.S. Petrikov, E.V. Roitman, A.M. Ronenson, A.A. Smetkin, A.A. Sokolov, S.M. Stepanenko, V.V. Subbotin, N.D. Ushakova, V.E. Khoronenko, S.V. Tsarenko, E.M. Shifman, D.L. Shukevich, A.V. Shchegolev, A.I. Yaroshetskiy, M.B. Yarustovsky, Anesthesia and intensive care for patients with COVID-19. Russian Federation of anesthesiologists and reanimatologists guidelines , Annals of Critical Care: Issue 1-S (2020): Supplement
R.V. Veyler, N.V. Trembach, T.S. Musaeva, M.A. Magomedov, A.S. Popov, V.V. Fisher, V.E. Khoronenko, A.I. Gritsan, P.V. Dunts, A.Zh. Bayalieva, A.M. Ovezov, K.M. Lebedinskii, D.V. Martynov, A.P. Spasova, V.V. Stadler, D.A. Levit, K.G. Shapovalov, V.N. Kokhno, V.V. Golubtsov, Igor B. Zabolotskikh, Prediction model for postoperative pneumonia in abdominal surgery: results of an observational multicenter study , Annals of Critical Care: Issue 4 (2023)
Igor B. Zabolotskikh, N.V. Trembach, T.S. Musaeva, P.V. Dunts, V.V. Golubtsov, E.V. Grigoryev, A.I. Gritsan, M.N. Zamyatin, V.N. Kokhno, A.N. Kuzovlev, K.M. Lebedinskii, M.A. Magomedov, Yu.P. Malyshev, A.M. Ovezov, A.S. Popov, D.N. Protsenko, V.V. Fisher, V.E. Khoronenko, National multicenter prospective observational study “The role of concomitant diseases in poSTOPerative complications RISK stratification — STOPRISK”: study protocol , Annals of Critical Care: Issue 4 (2022)
Igor B. Zabolotskikh, E.S. Gorobets, E.V. Grigoryev, Yu.V. Kotovskaya, K.M. Lebedinskii, T.S. Musaeva, E.A. Mkhitaryan, A.M. Ovechkin, V.S. Ostapenko, A.V. Rozanov, N.K. Runikhina, O.N. Tkacheva, N.V. Trembach, V.E. Khoronenko, M.A. Cherdak, Perioperative management of elderly and senile patients. Recommendations , Annals of Critical Care: Issue 3 (2022)

1 2 > >>

Double-blind, randomized, placebo-controlled study of Xenon in cancer pain therapy

Keywords

How to Cite

Statistic

Language

block-menu

Announcements

2022/07/14 The result of the annual update.

2022/06/11 The journal has just been assigned the internal Scopus number.

Abstract

References

Most read articles by the same author(s)

Double-blind, randomized, placebo-controlled study of Xenon in cancer pain therapy

Keywords

How to Cite

Download Citation

Statistic

Language

block-menu

Announcements

2022/07/14 The result of the annual update.

2022/06/11 The journal has just been assigned the internal Scopus number.

Social Networks

Abstract

References

Most read articles by the same author(s)