Efficacy of using helium-oxygen mixture in the intensive care of pneumonia in adult patients: a systematic review and meta-analysis
Issue 2 (2022) , INTENSIVE CARE OF RESPIRATORY FAILURE
Issue 2 (2022)
INTENSIVE CARE OF RESPIRATORY FAILURE

Efficacy of using helium-oxygen mixture in the intensive care of pneumonia in adult patients: a systematic review and meta-analysis

https://doi.org/10.21320/1818-474X-2022-2-52-69
Published 29.04.2022
Roman E. Lakhin
Military Medical Academy, St. Petersburg, Russia
https://orcid.org/0000-0001-6819-9691
P.А. Shapovalov
Military Medical Academy, St. Petersburg, Russia
https://orcid.org/0000-0003-0639-017X
A.V. Shchegolev
Military Medical Academy, St. Petersburg, Russia
https://orcid.org/0000-0001-6431-439X
K.V. Kozlov
Military Medical Academy, St. Petersburg, Russia
https://orcid.org/0000-0002-4398-7525
A.D. Zhdanov
Military Medical Academy, St. Petersburg, Russia
https://orcid.org/0000-0003-1459-501X
#2022-2
PDF_2022-2_52-69 (Русский)
HTML_2022-2_52-69 (Русский)

Keywords

pneumonia
helium
heliox
oxygen saturation
cough
adult
meta-analysis
systematic review

How to Cite

Lakhin R.E., Shapovalov P.А., Shchegolev A.V., Kozlov K.V., Zhdanov A.D. Efficacy of using helium-oxygen mixture in the intensive care of pneumonia in adult patients: a systematic review and meta-analysis. Annals of Critical Care. 2022;(2):52–69. doi:10.21320/1818-474X-2022-2-52-69.
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver AMA GOST

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Statistic

Abstract Views: 42
PDF_2022-2_52-69 (Русский) Downloads: 22
HTML_2022-2_52-69 (Русский) Downloads: 41
Statistic from 21.01.2023

Language

English Русский

Announcements

Social Networks

Abstract

OBJECTIVES. Evaluation of the effect addition helium-oxygen mixture (HOM) in adult patients with pneumonia compared with standard therapy. MATERIALS AND METHODS. Literature was searched in PubMed databases; Google Scholar and eLIBRARY.RU. The following factors were analyzed: the effect of HOM on mortality, SpO2 level, SpO2 recovery, C-reactive protein (CRP), ferritin, D-dimers, frequency of transfer to artificial lung ventilation, duration of stay in the intensive care unit (ICU), hospitalization, cough. Quality assessment, statistical data processing was performed in the Review Manager program, version 5.4.1. The reliability of evidence was evaluated using the GRADE approach using the GRADEpro GDT online program. RESULTS. The meta-analysis included 8 studies with a total of 1097 patients. In 4 out of 10 studied effects (mortality, ventilator rate, length of stay in the ICU, ferritin level), the results did not show the effect of adding HOM to standard therapy. A general meta-analysis of HOM effect showed an increase on SpO2 levels (MD: 1.68; 95% CI: 1.13–2.24; p < 0.001); the maximum effect was on 3–5 days and lasted up to 7 days. Positive effect HOM led to a faster recovery of SpO2 (MD: −2.91; 95% CI: −3.72 … −2.10; p < 0.001). Positive effect HOM led to reduction duration of hospitalization (MD: −3.40; 95% CI −6.05 … −0.76; p = 0.01), cough duration (MD: −3.00; 95% CI: −4.41 … −1.59; p < 0.001), CRP (MD: −16.83; 95% CI: −25.69 … −7.98; p = 0.0002), D-dimer (SMD: −0.48; 95% CI: −0.84 … −0.13; p = 0.007). CONCLUSIONS. The data obtained indicate that the addition of KGF to traditional therapy can improve oxygenation. The inclusion of HOM in therapy can reduce the duration of cough, as well as reduce the level CRP and D-dimers. There was no decrease in mortality, frequency of transfer to mechanical ventilation, duration of stay in the ICU.

https://doi.org/10.21320/1818-474X-2022-2-52-69
PDF_2022-2_52-69 (Русский)
HTML_2022-2_52-69 (Русский)

References

  1. Weber N.C., Preckel B. Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons. Intensive Care Med Exp. 2019; 7(1): DOI: 10.1186/s40635-019-0288-4
  2. Beurskens C.J., Brevoord D., Lagrand W.K., et al. Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation. Crit Care Res Pract. 2014; 2014: 954814. DOI: 10.1155/2014/954814
  3. Красновский А.Л., Григорьев С.П., Лошкарева Е.О. и др. Использование гелиокса в лечении больных с бронхолегочной патологией. Российский медицинский журнал. 2012; 5: 46–51. [Krasnovsky L., Grigoriyev S.P., Loshkareva E.O., et al. The application of geliox in treatment of patients with broncho-pulmonary pathology. Russian Medical Journal. 2012; 5: 46–51. (In Russ)]
  4. Beurskens C.J., Aslami H., de Beer F.M., et al. Heliox allows for lower minute volume ventilation in an animal model of ventilator-induced lung injury. PLoS One. 2013; 8(10): e78159. DOI: 10.1371/journal.pone.0078159
  5. Красновский А.Л., Григорьев С.П., Алехин А.И. и др. Применение подогреваемой кислородно-гелиевой смеси в комплексном лечении пациентов с внебольничной пневмонией. Клиническая медицина. 2013; 91(5): 38–41. [Krasnovsky A.L., Grogoriev S.P., Alekhin A.I., et al. Application of heated oxygen-helium mixture for combined treatment of community acquired pneumonia. Klinicheskaia meditsina. 2013; 91(5): 38–41. (In Russ)]
  6. Beurskens C.J., Wösten-van Asperen R.M., Preckel B., Juffermans N.P. The potential of heliox as a therapy for acute respiratory distress syndrome in adults and children: a descriptive review. 2015; 89(2): 166–74. DOI:10.1159/000369472
  7. Rodrigo G., Pollack C., Rodrigo C., Rowe B. Heliox for treatment of exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2002; 2001(2): DOI:10.1002/14651858.CD003571
  8. Gainnier M., Forel J.M. Clinical review: use of helium-oxygen in critically ill patients. Crit Care. 2006; 10(6): DOI: 10.1186/CC5104
  9. Lew A., Morrison J.M., Amankwah E., et al. Heliox for Pediatric Critical Asthma: A Multicenter, Retrospective, Registry-Based Descriptive Study. J Intensive Care Med. 2021; 8850666211026550. DOI: 10.1177/08850666211026550
  10. Valli G., Paoletti P., Savi D., et al. Clinical use of Heliox in asthma and COPD. Monaldi Arch Chest Dis. 2007; 67(3): 159–64.
  11. Liet J.M., Ducruet T., Gupta V., Cambonie G. Heliox inhalation therapy for bronchiolitis in infants. Cochrane Database Syst Rev. 2015; 2015(9): DOI: 10.1002/14651858.CD006915.pub3
  12. Moraa I., Sturman N., McGuire T.M., van Driel M.L. Heliox for croup in children. Cochrane Database Syst Rev. 2021; 8(8): DOI: 10.1002/14651858.CD006822.PUB6
  13. Hopster K., Duffee L.R., Hopster-Iversen C.C.S., Driessen B. Efficacy of an alveolar recruitment maneuver for improving gas exchange and pulmonary mechanics in anesthetized horses ventilated with oxygen or a helium-oxygen mixture. Am J Vet Res. 2018; 79(10): 1021– DOI:10.2460/ajvr.79.10.1021
  14. Higgins J.P.T., Savović J., Page M.J., Elbers R.G., Sterne J.A.C. Chapter 8: Assessing risk of bias in a randomized trial. In: Higgins J.P.T., Thomas J., Chandler J., Cumpston M., Li T., Page M.J., Welch V.A. (eds). Cochrane Handbook for Systematic Reviews of Interventions version 6.2 (updated February 2021). Cochrane, 2021. Available from: www.training.cochrane.org/handbook
  15. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. NY: Routledge, 1988. 567 DOI: 10.4324/9780203771587
  16. Schünemann H., Brożek J., Guyatt G., et al. GRADE handbook for grading quality of evidence and strength of recommendations. (Updated October 2013) In: The GRADE Working Group. Available from: https://gdt.gradepro.org/app/handbook/handbook.html
  17. Петриков С.С., Журавель С.В., Шогенова Л.В. и др. Термическая гелий-кислородная смесь в лечебном алгоритме больных с COVID-19. Вестник РАМН. 2020; 75: 353–62. DOI: 15690/vramn1412 [Petrikov S.S., Zhuravel S.V., Shogenova L.V., et al. Thermal Helium-Oxygen Mixture as Part of a Treatment Protocol for Patients with COVID-19. Annals of the Russian Academy of Medical Sciences. 2020; 75: 353–62. DOI: 10.15690/vramn1412 (In Russ)]
  18. Шогенова Л.В., Варфоломеев С.Д., Быков В.И. и др. Влияние термической гелий-кислородной смеси на вирусную нагрузку при COVID-19. Пульмонология. 2020; 30(5): 533–43. DOI: 18093/0869-0189-2020-30-5-533-543 [Shogenova L.V., Varfolomeev S.D., Bykov V.I., et al. Effect of thermal helium-oxygen mixture on viral load in COVID-19. Pul’monologiya. 2020; 30(5): 533–43. DOI: 10.18093/0869-0189-2020-30-5-533-543 (In Russ)]
  19. Варфоломеев С.Д., Журавель С.В., Панин А.А. и др. Термовакцинация — термогелиокс как стимулятор иммунного ответа. Кинетика синтеза антител и С-реактивного белка при коронавирусной инфекции. Доклады Российской академии наук. Науки о жизни. 2021; 496: 94–8. [Varfolomeev S.D., Zhuravel S.V., Panin A.A., et al. Thermovaccination — thermoheliox as an immune response stimulator. Kinetics of antibodies and C-reactive protein synthesis in coronaviral infection. Reports of the Russian academy of sciences. Life sciences. 2021; 496: 94–8. (In Russ)]
  20. Лахин Р.Е., Жданов А.Д., Щёголев А.В. и др. Применение кислородно-гелиевой газовой смеси «ГелиОкс» для лечения дыхательной недостаточности у пациентов с новой коронавирусной инфекцией COVID-19 (рандомизированное одноцентровое контролируемое исследование). Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2021; 10(3): 430–7. DOI: 23934/2223-9022-2021-10-3-430-437 [Lakhin R.E., Zhdanov A.D., Shchegolev A.V., et al. Oxygen-Helium Gas Mixture “Heliox” for the Treatment of Respiratory Failure in Patients with New Coronavirus Infection Covid-19 (Randomized Single-Center Controlled Trial). Russian Sklifosovsky Journal “Emergency Medical Care”. 2021; 10(3): 430–7. DOI: 10.23934/2223-9022-2021-10-3-430-437 (In Russ)]
  21. Мануйлов В.М., Суворов А.В., Куркин С.В. и др. Оценка эффективности кислородно-гелиевой терапии у больных с COVID-19 ассоциированной пневмонией. Авиакосмическая и экологическая медицина 2021; 55: 51–8. DOI: 21687/0233-528X-2021-55-1-51-58 [Manuilov V.M., Suvorov А.V., Kurkin S.V., et al. Evaluation of the oxygen-helium therapy efficiency for patients with covid-19 associated pneumonia. Aviakosmicheskaya i ekologicheskaya meditsina. 2021; 55: 51–8. DOI: 10.21687/0233-528X-2021-55-1-51-58 (In Russ)]
  22. Соколова О.П., Макарова А.В., Серезвин И.С. и др. Опыт применения гелиокса в лечении вирусной пневмонии при COVID-19. Медицинский альянс. 2021; 9(2): 8–14. DOI: 36422/23076348-2021-9-2-8-14 [Sokolova O., Makarova A., Serezvin I., et al. Experience of using heliox in the treatment of viral pneumonia in COVID-19. Meditsinskiy al’yans. 2021; 9(2): 8–14. DOI: 10.36422/23076348-2021-9-2-8-14 (In Russ)]
  23. Jolliet P., Tassaux D., Roeseler J., et al. Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter study. Crit Care Med. 2003; 31(3): 878–84. DOI: 10.1097/01.CCM.0000055369.37620.EE
  24. Jolliet P., Ouanes-Besbes L., Abroug F., et al. A Multicenter Randomized Trial Assessing the Efficacy of Helium/Oxygen in Severe Exacerbations of Chronic Obstructive Pulmonary Disease [published correction appears in Am J Respir Crit Care Med. 2018; 197(6): 839–40]. Am J Respir Crit Care Med. 2017; 195(7): 871– DOI:10.1164/rccm.201601-0083OC
  25. Maggiore S.M., Richard J.C., Abroug F., et al. A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease. Crit Care Med. 2010; 38(1): 145– DOI:10.1097/CCM.0b013e3181b78abe
  26. Neumann-Klimasińska N., Merritt T.A., Beck J., et al. Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants. Sci Rep. 2021; 11(1): 15778. DOI: 10.1038/S41598-021-95444-2
  27. Deng R.M., Li H.Y., Li X., et al. Neuroprotective effect of helium after neonatal hypoxic ischemia: a narrative review. Med Gas Res. 2021; 11(3): 121–3. DOI: 10.4103/2045-9912.314332
  28. Ma J., Tang S., Shen L., et al. A randomized single-center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome. Pediatr Pulmonol. 2021; 56(7): 2087– DOI:10.1002/ppul.25390
  29. Hunt T., Williams M.T., Frith P., Schembri D. Heliox, dyspnoea and exercise in COPD. Eur Respir Rev. 2010; 19(115): 30– DOI:10.1183/09059180.00006009
  30. El-Khatib M.F., Jamaleddine G., Kanj N., et al. Effect of heliox- and air-driven nebulized bronchodilator therapy on lung function in patients with asthma. Lung. 2014; 192(3): 377–83. DOI: 10.1007/s00408-014-9570-0
  31. Rodrigo G.J., Castro-Rodriguez J.A. Heliox-driven β2-agonists nebulization for children and adults with acute asthma: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2014; 112(1): 29– DOI:10.1016/j.anai.2013.09.024
  32. COPD Working Group. Noninvasive positive pressure ventilation for chronic respiratory failure patients with stable chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012; 12(9): 1–
  33. Long C., Li W., Wanwei L., Jie L., Yuan S. Noninvasive Ventilation with Heliox for Respiratory Distress Syndrome in Preterm Infant: A Systematic Review and Meta-Analysis. Can Respir J. 2016: DOI: 10.1155/2016/9092871
  34. Elleau C., Galperine R.I., Guenard H., Demarquez J.L. Helium-oxygen mixture in respiratory distress syndrome: a double-blind study. J Pediatr. 1993; 122(1): 132– DOI:10.1016/s0022-3476(05)83506-1
  35. Seliem W., Sultan A.M. Heliox delivered by high flow nasal cannula improves oxygenation in infants with respiratory syncytial virus acute bronchiolitis. J Pediatr (Rio J). 2018; 94(1): 56–61. DOI: 10.1016/j.jped.2017.04.004
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Copyright (c) 2022 ANNALS OF CRITICAL CARE

Most read articles by the same author(s)

1 2 3 > >>